| Rank | Company | Operating income | Sector | Industry | Country | Exchange |
|---|---|---|---|---|---|---|
| 1 | $16.9B | Healthcare | Pharmaceuticals | United States | NYSE | |
| 2 | $7.35B | Healthcare | Pharmaceuticals | United States | NYSE | |
| 3 | $4.78B | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 4 | $3.84B | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 5 | $1.51B | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 6 | $1.40B | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 7 | $1000M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 8 | $897M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 9 | $883M | Healthcare | Pharmaceuticals | United States | NYSE | |
| 10 | $454M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 11 | $421M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 12 | $290M | Healthcare | Pharmaceuticals | United States | NYSE | |
| 13 | $234M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 14 | $231M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 15 | $217M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 16 | $194M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 17 | $169M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 18 | $163M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 19 | $157M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 20 | $151M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 21 | $150M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 22 | $149M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 23 | $149M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 24 | $136M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 25 | $126M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 26 | $117M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 27 | $114M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 28 | $100M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 29 | $94.7M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 30 | $87.0M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 31 | $86.4M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 32 | $82.4M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 33 | $58.3M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 34 | $36.6M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 35 | $34.3M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 36 | $30.4M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 37 | $29.3M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 38 | $21.5M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 39 | $19.9M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 40 | $16.3M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 41 | $9.56M | Healthcare | Pharmaceuticals | United States | NYSE | |
| 42 | $9.19M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 43 | $6.41M | Healthcare | Pharmaceuticals | United States | Nasdaq | |
| 44 | $6.03M | Healthcare | Pharmaceuticals | United States | Nasdaq |