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    SNTI

    Senti Biosciences Holdings, Inc.

    Company overview

    Market capitalization
    $9.65M
    Employees
    39
    Latest publication
    2026-09-29
    About Senti Biosciences Holdings, Inc.

    Senti Biosciences Holdings, Inc., a clinical stage biotechnology company, develops cell and gene therapies engineered with its gene circuit platform technologies for patients living with incurable diseases. The company's lead product candidates utilize off-the-shelf healthy adult donor derived natural killer (NK) cells to create CAR-NK cells outfitted with gene circuit technologies in various oncology indications with unmet need. It offers SENTI-202, a logic gated off-the-shelf CAR-NK cell therapy for the treatment of blood cancers and relapsed/refractory hematological malignancies, including acute myeloid leukemia. In addition, the company develops the tumor-associated antigen and protective antigen paired discovery platform to select and validate NOT GATE antigen candidates and identify tumor-associated antigens in cancer cells. Further, its pipeline includes preclinical programs, which comprise a solid tumor cell therapy program; and partnered programs related to cell therapies for regenerative medicines. The company has a strategic collaboration with Celest Therapeutics (Shanghai) Co. Ltd. The company was formerly known as Senti Biosciences, Inc. and changed its name to Senti Biosciences Holdings, Inc. in April 2026. The company was incorporated in 2016 and is headquartered in South San Francisco, California.

    Company website

    Financial statements

    Income Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ2 20262026-06-30 · USDQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Total Revenue17,000USD16,000USD22,000USD0USD0USD0USD0USD0USD
    Research Development7,767,000USD5,281,000USD7,760,000USD10,516,000USD9,805,000USD9,281,000USD8,655,000USD8,896,000USD
    Selling General Administrative6,739,000USD5,764,000USD5,846,000USD5,755,000USD6,769,000USD6,415,000USD6,247,000USD4,205,000USD
    General And Administrative Expenses6,739,000USD———————
    Total Operating Expenses14,506,000USD11,514,000USD12,713,000USD16,948,000USD15,322,000USD16,397,000USD15,215,000USD11,889,000USD
    Operating Income-14,489,000USD-11,498,000USD-13,584,000USD-16,948,000USD-16,798,000USD-16,397,000USD-15,215,000USD-13,356,000USD
    Total Other Income Expense Net1,739,000USD7,277,000USD-883,000USD-1,178,000USD2,065,000USD2,285,000USD-13,651,000USD2,153,000USD
    Income Before Tax-12,750,000USD-4,221,000USD-14,467,000USD-18,126,000USD-14,733,000USD-14,112,000USD-28,866,000USD-11,203,000USD
    Income Tax Expense0USD———————
    Net Income-12,750,000USD-4,221,000USD-14,467,000USD-18,126,000USD-14,733,000USD-14,112,000USD-28,866,000USD-11,203,000USD
    Gross Profit—16,000USD-871,000USD-904,000USD-1,476,000USD-926,000USD-1,464,000USD-1,467,000USD
    Interest Income—101,000USD97,000USD166,000USD270,000USD394,000USD150,000USD236,000USD
    Net Interest Income—101,000USD97,000USD166,000USD270,000USD394,000USD150,000USD236,000USD
    Net Income From Continuing Ops—-4,221,000USD-14,467,000USD-18,126,000USD-14,733,000USD-14,112,000USD-28,866,000USD-11,203,000USD
    Ebit—-4,221,000USD-14,467,000USD-18,126,000USD-14,733,000USD-14,112,000USD-14,902,000USD-11,203,000USD
    Ebitda—-3,533,000USD-13,574,000USD-17,449,000USD-13,257,000USD-12,644,000USD-13,438,000USD-9,736,000USD
    Depreciation And Amortization—688,000USD893,000USD677,000USD1,476,000USD1,468,000USD1,464,000USD1,467,000USD
    Reconciled Depreciation—688,000USD893,000USD-200,000USD1,476,000USD1,468,000USD1,464,000USD1,467,000USD
    Cost Of Revenue——893,000USD904,000USD1,476,000USD——1,467,000USD
    Unclassified Operating Expenses————-1,252,000USD——-1,212,000USD
    SourceDisclosureDeterministicFinalLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Income Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20242024-12-31 · USDFY 20222022-12-31 · USDFY 20212021-12-31 · USDFY 20202020-12-31 · USD
    Total Revenue0USD4,286,000USD2,291,000USD394,000USD
    Research Development34,356,000USD34,067,000USD21,957,000USD15,956,000USD
    Selling General Administrative23,510,000USD40,848,000USD21,250,000USD9,304,000USD
    Unclassified Operating Expenses3,173,000USD———
    Total Operating Expenses61,039,000USD74,915,000USD42,737,000USD25,088,000USD
    Operating Income-61,039,000USD-70,629,000USD-40,446,000USD-24,694,000USD
    Interest Income948,000USD1,701,000USD11,000USD88,000USD
    Net Interest Income948,000USD1,701,000USD11,000USD88,000USD
    Income Before Tax-52,790,000USD-58,210,000USD-55,319,000USD-19,862,000USD
    Net Income-52,790,000USD-45,791,000USD-55,319,000USD-19,862,000USD
    Net Income From Continuing Ops-52,790,000USD-58,210,000USD-55,319,000USD-19,862,000USD
    Ebit-60,726,000USD-70,629,000USD-55,319,000USD-24,694,000USD
    Ebitda-54,875,000USD-66,709,000USD-52,309,000USD-22,709,000USD
    Depreciation And Amortization5,851,000USD3,920,000USD3,010,000USD1,985,000USD
    Reconciled Depreciation5,851,000USD3,920,000USD3,010,000USD1,985,000USD
    Total Other Income Expense Net8,249,000USD12,419,000USD-14,873,000USD4,832,000USD
    Cost Of Revenue—3,920,000USD3,010,000USD15,956,000USD
    Gross Profit—4,286,000USD2,291,000USD394,000USD
    Interest Expense—3,920,000USD11,000USD88,000USD
    Income Tax Expense—-12,419,000USD11,000USD150,000USD
    Non Operating Income Net Other—10,718,000USD——
    Net Income Applicable To Common Shares—-58,210,000USD-55,319,000USD-19,862,000USD
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ2 20262026-06-30 · USDQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USD
    Total Assets33,105,000USD38,241,000USD51,223,000USD52,685,000USD68,540,000USD82,778,000USD97,841,000USD57,721,000USD
    Cash And Equivalents6,463,000USD———————
    Total Current Assets13,007,000USD14,790,000USD23,274,000USD18,158,000USD32,521,000USD45,213,000USD58,961,000USD17,384,000USD
    Other Current Assets288,000USD5,090,000USD5,259,000USD4,171,000USD7,349,000USD9,266,000USD8,879,000USD12,541,000USD
    Other Non Current Assets0USD———————
    Total Liabilities36,506,000USD———————
    Total Current Liabilities15,765,000USD14,268,000USD13,974,000USD12,027,000USD9,987,000USD10,726,000USD13,146,000USD9,064,000USD
    Other Non Current Liabilities8,000,000USD———————
    Total Stockholder Equity-3,401,000USD2,565,000USD5,589,000USD8,121,000USD24,652,000USD37,859,000USD25,649,000USD15,994,000USD
    Total Equity Including Noncontrolling Interest-3,401,000USD———————
    Deferred Revenue11,000USD———————
    Property Plant Equipment Net18,672,000USD19,918,000USD24,402,000USD30,953,000USD32,438,000USD33,940,000USD35,237,000USD36,688,000USD
    Accounts Payable2,248,000USD1,052,000USD2,943,000USD1,771,000USD1,020,000USD1,559,000USD1,454,000USD793,000USD
    Short Term Debt3,492,000USD5,891,000USD5,330,000USD5,153,000USD4,979,000USD4,811,000USD4,750,000USD4,589,000USD
    Common Stock3,000USD3,000USD3,000USD3,000USD3,000USD3,000USD1,000USD1,000USD
    Retained Earnings-375,543,000USD-362,793,000USD-358,572,000USD-344,105,000USD-325,979,000USD-311,246,000USD-297,134,000USD-296,524,000USD
    Total Liab—35,676,000USD45,634,000USD44,564,000USD43,888,000USD44,919,000USD72,192,000USD41,727,000USD
    Other Current Liab—5,030,000USD5,354,000USD5,103,000USD3,628,000USD3,843,000USD6,282,000USD3,043,000USD
    Capital Stock—3,000USD3,000USD3,000USD3,000USD3,000USD1,000USD1,000USD
    Cash—8,935,000USD16,420,000USD12,243,000USD21,576,000USD33,802,000USD48,277,000USD10,479,000USD
    Cash And Short Term Investments—8,935,000USD16,420,000USD12,243,000USD21,576,000USD33,802,000USD48,277,000USD10,479,000USD
    Current Deferred Revenue—2,295,000USD347,000USD—360,000USD513,000USD660,000USD639,000USD
    Net Debt—10,206,000USD12,471,000USD17,878,000USD9,735,000USD-1,357,000USD-14,636,000USD24,230,000USD
    Short Long Term Debt Total—19,141,000USD28,891,000USD30,121,000USD31,311,000USD32,445,000USD33,641,000USD34,709,000USD
    Net Receivables—765,000USD1,595,000USD1,744,000USD3,692,000USD2,218,000USD1,805,000USD74,000USD
    Property Plant Equipment Gross—33,497,000USD37,459,000USD43,117,000USD43,700,000USD44,417,000USD44,788,000USD45,316,000USD
    Common Stock Shares Outstanding—30,971,573shares22,483,391shares26,228,274shares26,081,273shares4,595,946shares4,595,946shares4,577,122shares
    Non Current Assets Total—23,451,000USD27,949,000USD34,527,000USD36,019,000USD37,565,000USD38,880,000USD40,337,000USD
    Non Current Liabilities Total—21,408,000USD31,660,000USD32,537,000USD33,901,000USD34,193,000USD59,046,000USD32,663,000USD
    Non Current Liabilities Other—208,000USD149,000USD149,000USD149,000USD149,000USD5,049,000USD2,543,000USD
    Non Currrent Assets Other—5,000USD3,547,000USD3,574,000USD3,581,000USD3,625,000USD3,643,000USD3,649,000USD
    Net Working Capital—522,000USD9,300,000USD6,131,000USD22,534,000USD34,487,000USD45,815,000USD8,320,000USD
    Unclassified Non Current Assets—3,528,000USD——————
    Unclassified Non Current Liabilities—21,200,000USD31,511,000USD32,388,000USD33,752,000USD34,044,000USD53,997,000USD30,120,000USD
    Unclassified Equity—365,352,000USD364,155,000USD352,220,000USD350,625,000USD349,099,000USD322,781,000USD312,516,000USD
    Inventory——————335,000USD—
    Unclassified Current Assets———————-5,710,000USD
    SourceDisclosureDeterministicFinalLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USDFY 20212021-12-31 · USDFY 20202020-12-31 · USDFY 20192019-12-31 · USD
    Total Assets51,223,000USD97,841,000USD119,484,000USD180,792,000USD96,702,000USD48,345,000USD35,842,000USD
    Other Current Assets5,259,000USD8,879,000USD17,570,000USD3,390,000USD2,230,000USD855,000USD853,000USD
    Total Liab45,634,000USD72,192,000USD52,571,000USD53,529,000USD36,326,000USD107,058,000USD17,877,000USD
    Total Stockholder Equity5,589,000USD25,649,000USD66,913,000USD127,263,000USD60,376,000USD-58,713,000USD17,965,000USD
    Other Current Liab5,354,000USD6,282,000USD6,305,000USD12,999,000USD5,957,000USD2,433,000USD3,109,000USD
    Common Stock3,000USD1,000USD5,000USD4,000USD1,000USD1,000USD1,000USD
    Capital Stock3,000USD1,000USD5,000USD4,000USD1,000USD1,000USD—
    Retained Earnings-358,572,000USD-297,134,000USD-244,344,000USD-173,286,000USD-115,076,000USD-59,757,000USD-39,895,000USD
    Cash16,420,000USD48,277,000USD35,926,000USD57,621,000USD56,034,000USD30,537,000USD5,301,000USD
    Cash And Short Term Investments16,420,000USD48,277,000USD35,926,000USD98,563,000USD56,034,000USD30,537,000USD17,829,000USD
    Total Current Assets23,274,000USD58,961,000USD71,200,000USD102,579,000USD58,747,000USD31,709,000USD18,760,000USD
    Total Current Liabilities13,974,000USD13,146,000USD12,672,000USD18,053,000USD14,543,000USD4,866,000USD4,306,000USD
    Current Deferred Revenue347,000USD660,000USD989,000USD799,000USD1,656,000USD1,998,000USD—
    Net Debt12,471,000USD-14,636,000USD1,740,000USD-20,530,000USD-33,303,000USD-16,488,000USD-5,301,000USD
    Short Term Debt5,330,000USD4,750,000USD4,128,000USD1,988,000USD1,743,000USD1,519,000USD—
    Short Long Term Debt Total28,891,000USD33,641,000USD37,666,000USD37,091,000USD22,731,000USD14,049,000USD—
    Net Receivables1,595,000USD1,805,000USD17,704,000USD626,000USD483,000USD317,000USD78,000USD
    Accounts Payable2,943,000USD1,454,000USD1,250,000USD2,267,000USD5,187,000USD914,000USD1,197,000USD
    Property Plant Equipment Net24,402,000USD35,237,000USD41,612,000USD74,554,000USD33,076,000USD16,139,000USD16,585,000USD
    Property Plant Equipment Gross37,459,000USD44,788,000USD47,794,000USD56,136,000USD34,731,000USD17,121,000USD—
    Common Stock Shares Outstanding224,833,910shares4,596,000shares4,437,222shares4,394,729shares4,365,707shares4,365,707shares1,358,690shares
    Non Current Assets Total27,949,000USD38,880,000USD48,284,000USD78,213,000USD37,955,000USD16,636,000USD16,585,000USD
    Non Current Liabilities Total31,660,000USD59,046,000USD39,899,000USD35,476,000USD21,783,000USD102,192,000USD—
    Non Current Liabilities Other149,000USD5,049,000USD20,000USD373,000USD———
    Non Currrent Assets Other19,000USD3,643,000USD2,031,000USD293,000USD1,622,000USD497,000USD-16,585,000USD
    Net Working Capital9,300,000USD45,815,000USD58,528,000USD84,526,000USD45,650,000USD26,843,000USD—
    Unclassified Non Current Assets3,528,000USD—4,640,999USD————
    Unclassified Non Current Liabilities31,511,000USD53,997,000USD39,879,000USD34,730,000USD20,988,000USD102,192,000USD—
    Unclassified Equity364,155,000USD322,781,000USD430,731,000USD300,540,000USD347,283,000USD90,704,000USD57,859,000USD
    Inventory—335,000USD—3,289,000USD2,603,000USD25,000USD—
    Other Assets——1USD3,659,000USD3,433,000USD497,000USD497,000USD
    Short Term Investments——0USD40,942,000USD1,157,000USD25,000USD12,528,000USD
    Accumulated Other Comprehensive Income——-119,484,000USD1,000USD-171,833,000USD-89,662,000USD—
    Other Liab———373,000USD795,000USD——
    Net Tangible Assets———127,263,000USD-111,457,000USD-58,713,000USD-39,443,000USD
    Unclassified Current Assets———-3,289,000USD-3,760,000USD——
    Unclassified Current Liabilities—————-1,998,000USD—
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow YTD

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ2 20262026-06-30 · USD
    Depreciation1,355,000USD
    Stock Based Compensation2,363,000USD
    Change To Liabilities-1,942,000USD
    Change In Working Capital-702,000USD
    Operating Cash Flow-21,730,000USD
    Capital Expenditures0USD
    Unclassified Investing Cash Flow114,000USD
    Investing Cash Flow114,000USD
    Net Common Stock Issuance-118,000USD
    Unclassified Financing Cash Flow9,675,000USD
    Financing Cash Flow9,557,000USD
    Change In Cash-12,059,000USD
    End Cash Flow7,889,000USD
    SourceDisclosureDeterministicFinal

    Cash flow Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Net Income-4,221,000USD-14,467,000USD-18,126,000USD-14,733,000USD-14,112,000USD-610,000USD-28,866,000USD-11,203,000USD
    Depreciation688,000USD1,455,000USD-200,000USD1,476,000USD926,000USD1,459,000USD1,464,000USD1,467,000USD
    Stock Based Compensation1,315,000USD1,425,000USD1,551,000USD1,526,000USD1,204,000USD605,000USD668,000USD-776,000USD
    Other Non Cash Items-6,709,000USD4,490,000USD447,000USD39,000USD1,204,000USD-13,499,000USD16,489,000USD-254,000USD
    Change To Account Receivables830,000USD149,000USD1,948,000USD-1,474,000USD-413,000USD-542,000USD-40,000USD-130,000USD
    Change In Working Capital1,446,000USD222,000USD7,329,000USD-1,381,000USD-2,068,000USD-1,459,000USD3,047,000USD2,421,000USD
    Total Cash From Operating Activities-7,481,000USD-6,875,000USD-9,446,000USD-13,073,000USD-14,050,000USD-13,504,000USD-7,866,000USD-8,345,000USD
    Capital Expenditures0USD0USD0USD-196,000USD0USD-11,000USD0USD0USD
    Free Cash Flow-7,481,000USD-6,875,000USD-9,446,000USD-13,269,000USD-14,050,000USD-13,515,000USD-7,866,000USD-8,345,000USD
    Total Cashflows From Investing Activities114,000USD12,000USD-12,000USD-184,000USD—-11,000USD60,000USD—
    Total Cash From Financing Activities-118,000USD11,039,999USD124,000USD1,010,999USD-414,000USD51,290,000USD2,440,000USD0USD
    Change In Cash-7,485,000USD4,165,000USD-9,322,000USD-12,226,000USD-14,464,000USD37,798,000USD-5,381,000USD-8,345,000USD
    Begin Period Cash Flow19,948,000USD15,783,000USD25,105,000USD33,802,000USD51,815,000USD10,479,000USD15,860,000USD27,751,000USD
    End Period Cash Flow12,463,000USD19,948,000USD15,783,000USD21,576,000USD37,351,000USD48,277,000USD10,479,000USD19,406,000USD
    Other Cashflows From Investing Activities114,000USD—————60,000USD—
    Other Cashflows From Financing Activities-118,000USD529,999USD-12,000USD—-414,000USD2,470,000USD2,430,000USD—
    Issuance Of Capital Stock—-670,000USD136,000USD——49,049,000USD10,000USD—
    Unclassified Financing Cash Flow—11,180,000USD———51,260,000USD-2,430,000USD—
    Investments——0USD-184,000USD0USD-11,000USD60,000USD0USD
    Unclassified Operating Cash Flow————-1,204,000USD———
    Net Borrowings—————-2,430,000USD2,430,000USD—
    Sale Purchase Of Stock—————-10,000USD10,000USD—
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20212021-12-31 · USDFY 20202020-12-31 · USDFY 20192019-12-31 · USD
    Net Income-61,438,000USD-52,790,000USD-71,058,000USD-55,319,000USD-19,862,000USD-21,157,000USD
    Depreciation3,637,000USD5,851,000USD5,429,000USD3,010,000USD1,985,000USD1,396,000USD
    Stock Based Compensation5,706,000USD1,755,000USD9,670,000USD2,295,000USD272,000USD205,000USD
    Other Non Cash Items5,091,000USD-256,000USD-1,101,000USD14,764,000USD-4,793,000USD1,383,000USD
    Change To Account Receivables210,000USD-727,000USD-929,000USD-395,000USD-10,000USD124,000USD
    Change In Working Capital3,560,000USD4,043,000USD4,665,000USD615,000USD-1,775,000USD124,000USD
    Total Cash From Operating Activities-43,444,000USD-41,397,000USD-52,395,000USD-34,635,000USD-24,173,000USD-18,378,000USD
    Capital Expenditures-196,000USD-26,000USD-12,038,000USD-5,543,000USD-1,161,000USD-1,996,000USD
    Free Cash Flow-43,640,000USD-41,423,000USD-64,433,000USD-40,178,000USD-25,334,000USD-20,374,000USD
    Total Cashflows From Investing Activities-184,000USD34,000USD30,077,000USD-5,543,000USD11,358,000USD3,751,000USD
    Total Cash From Financing Activities11,761,000USD53,730,000USD779,000USD68,435,000USD38,051,000USD14,012,000USD
    Issuance Of Capital Stock0USD49,059,000USD512,000USD67,000,000USD30,000,000USD—
    Change In Cash-31,867,000USD12,367,000USD-21,539,000USD28,257,000USD25,236,000USD5,798,000USD
    Begin Period Cash Flow51,815,000USD39,448,000USD60,987,000USD31,034,000USD5,798,000USD—
    End Period Cash Flow19,948,000USD51,815,000USD39,448,000USD59,291,000USD31,034,000USD5,798,000USD
    Other Cashflows From Investing Activities12,000USD60,000USD105,000USD—12,519,000USD5,747,000USD
    Other Cashflows From Financing Activities3,050,000USD4,671,000USD375,000USD68,435,000USD30,051,000USD14,012,000USD
    Unclassified Financing Cash Flow8,711,000USD——-66,979,106USD-30,000,000USD-8,000,000USD
    Investments—34,000USD-19,142,000USD-5,543,000USD12,519,000USD5,732,000USD
    Net Borrowings—0USD-108,000USD-17,000USD8,000,000USD8,000,000USD
    Dividends Paid——-404,000USD-3,894USD——
    Sale Purchase Of Stock——512,000USD———
    Unclassified Investing Cash Flow——61,152,000USD5,543,000USD-12,519,000USD-5,732,000USD
    Change To Inventory———-205,000USD-1,606,000USD—
    Change To Liabilities———1,215,000USD-159,000USD628,000USD
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Operating metrics

    No operating metrics are currently published for this company.

    Revenue breakdown

    No revenue breakdown is currently published for this company.

    Periods follow company fiscal calendars. Quarterly, annual and year-to-date amounts are shown separately. Missing values are not zero. Data may be delayed, incomplete or corrected; follow the disclosure links to verify figures.