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    SION

    Sionna Therapeutics, Inc.

    Company overview

    Market capitalization
    $231.49M
    Employees
    59
    Latest publication
    2026-09-29
    About Sionna Therapeutics, Inc.

    Sionna Therapeutics, Inc., a clinical-stage biopharmaceutical company, researches and develops medicines for the treatment of cystic fibrosis (CF). It develops galicaftor (SION-2222), a transmembrane domain 1 (TMD1)-directed cystic fibrosis transmembrane conductance regulator (CFTR) that has completed Phase 2 trial; navocaftor (SION-3067), a potentiator that has completed Phase 2 trial; SION-109, an intracellular loop 4 directed CFTR corrector that has completed Phase 1 trial; SION-2851, a TMD1-directed CFTR corrector that has completed Phase 1 trial; SION-451, which is nucleotide-binding domain 1 stabilizer in Phase 1 trial; and SION-719, which is nucleotide-binding domain 1 stabilizer in Phase 2a proof-of-concept trial. The company was formerly known as Sling Therapeutics, Inc. and changed its name to Sionna Therapeutics, Inc. in July 2021. Sionna Therapeutics, Inc. was incorporated in 2019 and is headquartered in Waltham, Massachusetts.

    Company website

    Financial statements

    Income Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Total Revenue0USD0USD0USD0USD0USD0USD0USD0USD
    Cost Of Revenue154,000USD152,000USD100,000USD147,000USD———166,000USD
    Gross Profit-154,000USD-152,000USD-100,000USD-147,000USD———-166,000USD
    Research Development18,963,000USD15,168,000USD16,044,000USD15,383,000USD13,668,000USD14,253,000USD24,582,000USD8,233,000USD
    Selling General Administrative10,636,000USD9,873,000USD7,241,000USD6,523,000USD5,560,000USD3,880,000USD4,158,000USD2,669,000USD
    Selling And Marketing Expenses154,000USD———————
    Total Operating Expenses29,445,000USD23,460,000USD23,805,000USD21,759,000USD19,659,000USD18,133,000USD27,984,000USD11,126,000USD
    Operating Income-29,599,000USD-23,612,000USD-23,805,000USD-21,906,000USD-19,659,000USD-18,133,000USD-27,984,000USD-11,292,000USD
    Interest Income2,820,000USD3,172,000USD3,456,000USD3,667,000USD3,000,000USD2,119,000USD2,353,000USD2,566,000USD
    Net Interest Income2,820,000USD3,172,000USD3,456,000USD3,667,000USD3,000,000USD2,119,000USD2,353,000USD2,566,000USD
    Income Before Tax-26,779,000USD-20,440,000USD-20,278,000USD-18,068,000USD-16,482,000USD-15,848,000USD-25,441,000USD-8,552,000USD
    Net Income-26,779,000USD-20,440,000USD-20,278,000USD-18,068,000USD-16,482,000USD-15,848,000USD-25,441,000USD-8,552,000USD
    Net Income From Continuing Ops-26,779,000USD-20,440,000USD-20,278,000USD-18,068,000USD-16,482,000USD-15,848,000USD-25,441,000USD-8,552,000USD
    Ebit-29,599,000USD-17,263,000USD-23,805,000USD-18,068,000USD-19,659,000USD-18,133,000USD-27,984,000USD-8,552,000USD
    Ebitda-29,445,000USD-17,941,000USD-23,285,000USD-17,921,000USD-19,228,000USD-17,966,000USD-27,815,000USD-8,386,000USD
    Depreciation And Amortization154,000USD-678,000USD520,000USD147,000USD431,000USD167,000USD169,000USD166,000USD
    Reconciled Depreciation154,000USD152,000USD189,000USD147,000USD159,000USD167,000USD169,000USD166,000USD
    Total Other Income Expense Net2,820,000USD3,172,000USD3,527,000USD3,838,000USD3,177,000USD2,285,000USD2,543,000USD2,740,000USD
    Unclassified Operating Expenses—-1,581,000USD——————
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Income Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USD
    Total Revenue0USD0USD0USD0USD
    Cost Of Revenue647,000USD668,000USD——
    Gross Profit-647,000USD-668,000USD——
    Research Development60,263,000USD57,288,000USD40,626,000USD34,605,000USD
    Selling General Administrative28,719,000USD13,268,000USD9,707,000USD6,767,000USD
    Total Operating Expenses88,335,000USD69,888,000USD50,333,000USD41,372,000USD
    Operating Income-88,982,000USD-70,556,000USD-50,333,000USD-41,372,000USD
    Interest Income13,295,000USD8,170,000USD2,769,000USD1,132,000USD
    Net Interest Income13,295,000USD8,170,000USD2,769,000USD1,132,000USD
    Income Before Tax-75,268,000USD-61,688,000USD-47,263,000USD-40,240,000USD
    Net Income-75,268,000USD-61,688,000USD-47,263,000USD-40,240,000USD
    Net Income From Continuing Ops-75,268,000USD-61,688,000USD-47,263,000USD-40,240,000USD
    Ebit-88,982,000USD-70,556,000USD-50,333,000USD-41,372,000USD
    Ebitda-88,335,000USD-69,888,000USD-49,750,000USD-41,250,000USD
    Depreciation And Amortization647,000USD668,000USD583,000USD122,000USD
    Reconciled Depreciation647,000USD668,000USD583,000USD122,000USD
    Total Other Income Expense Net13,714,000USD8,868,000USD3,070,000USD1,132,000USD
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ2 20262026-06-30 · USDQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USD
    Total Assets283,249,000USD305,039,000USD325,953,000USD339,270,000USD352,048,000USD369,674,000USD185,752,000USD197,265,000USD
    Cash And Equivalents63,322,000USD———————
    Total Current Assets216,130,000USD220,959,000USD241,419,000USD252,328,000USD266,746,000USD273,680,000USD150,993,000USD140,337,000USD
    Other Current Assets5,099,000USD4,809,000USD5,537,000USD3,999,000USD4,175,000USD4,014,000USD3,455,000USD2,863,000USD
    Other Non Current Assets594,000USD———————
    Total Liabilities17,474,000USD———————
    Total Current Liabilities10,782,000USD9,776,000USD11,712,000USD9,851,000USD7,550,000USD9,527,000USD10,420,000USD6,478,000USD
    Other Current Liabilities7,000USD———————
    Total Stockholder Equity265,775,000USD288,208,000USD306,833,000USD321,668,000USD336,429,000USD351,769,000USD-163,713,000USD-148,549,000USD
    Total Equity Including Noncontrolling Interest265,775,000USD———————
    Property Plant Equipment Net8,340,000USD8,751,000USD9,151,000USD9,309,000USD9,641,000USD10,010,000USD10,298,000USD10,646,000USD
    Short Term Debt1,377,000USD1,322,000USD1,269,000USD1,217,000USD1,168,000USD1,119,000USD1,072,000USD1,027,000USD
    Common Stock45,000USD45,000USD45,000USD44,000USD44,000USD44,000USD5,000USD5,000USD
    Retained Earnings-313,019,000USD-283,133,000USD-256,354,000USD-235,914,000USD-215,636,000USD-197,568,000USD-181,086,000USD-165,238,000USD
    Accumulated Other Comprehensive Income-448,000USD-84,000USD540,000USD420,000USD183,000USD301,000USD368,000USD773,000USD
    Total Liab—16,831,000USD19,120,000USD17,602,000USD15,619,000USD17,905,000USD349,465,000USD345,814,000USD
    Other Current Liab—6,345,000USD9,674,000USD7,153,000USD5,468,000USD3,389,000USD8,162,000USD5,347,000USD
    Capital Stock—45,000USD45,000USD44,000USD44,000USD44,000USD5,000USD5,000USD
    Cash—63,324,000USD58,451,000USD50,831,000USD40,985,000USD82,695,000USD37,788,000USD35,749,000USD
    Cash And Short Term Investments—216,150,000USD235,882,000USD248,329,000USD262,571,000USD269,666,000USD147,538,000USD137,474,000USD
    Net Debt—-54,947,000USD-49,774,000USD-41,863,000USD-31,748,000USD-73,198,000USD-28,039,000USD-25,754,000USD
    Short Long Term Debt Total—8,377,000USD8,677,000USD8,968,000USD9,237,000USD9,497,000USD9,749,000USD9,995,000USD
    Long Term Investments—73,781,000USD74,420,000USD76,671,000USD74,699,000USD85,022,000USD20,505,000USD43,400,000USD
    Short Term Investments—152,826,000USD177,431,000USD197,498,000USD221,586,000USD186,971,000USD109,750,000USD101,725,000USD
    Accounts Payable—2,109,000USD769,000USD1,481,000USD914,000USD5,019,000USD1,186,000USD104,000USD
    Property Plant Equipment Gross—11,027,000USD11,273,000USD11,279,000USD11,518,000USD11,740,000USD11,869,000USD12,050,000USD
    Common Stock Shares Outstanding—44,921,984shares39,962,163shares44,463,527shares44,132,338shares44,092,117shares44,124,394shares44,124,394shares
    Non Current Assets Total—84,080,000USD84,534,000USD86,941,999USD85,302,000USD95,994,000USD34,759,000USD56,928,000USD
    Non Current Liabilities Total—7,055,000USD7,408,000USD7,750,999USD8,069,000USD8,378,000USD339,045,000USD339,336,000USD
    Non Currrent Assets Other—75,329,000USD963,000USD77,633,000USD962,000USD962,000USD3,956,000USD2,882,000USD
    Net Working Capital—211,183,000USD229,707,000USD242,477,000USD259,196,000USD264,153,000USD140,573,000USD133,859,000USD
    Unclassified Non Current Assets—-73,781,000USD—-76,671,001USD————
    Unclassified Non Current Liabilities—7,055,000USD7,408,000USD7,750,999USD8,069,000USD8,378,000USD339,045,000USD339,336,000USD
    Unclassified Equity—571,335,000USD562,557,000USD557,074,000USD551,794,000USD548,948,000USD16,995,000USD15,906,000USD
    SourceDisclosureDeterministicFinalLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USD
    Total Assets325,953,000USD185,752,000USD51,945,000USD87,369,000USD
    Other Current Assets5,537,000USD3,455,000USD686,000USD1,223,000USD
    Total Liab19,120,000USD349,465,000USD166,826,000USD157,293,000USD
    Total Stockholder Equity306,833,000USD-163,713,000USD-114,881,000USD-69,924,000USD
    Other Current Liab9,674,000USD8,162,000USD6,590,000USD7,696,000USD
    Common Stock45,000USD5,000USD2,000USD2,000USD
    Capital Stock45,000USD5,000USD2,000USD2,000USD
    Retained Earnings-256,354,000USD-181,086,000USD-119,398,000USD-72,135,000USD
    Cash58,451,000USD37,788,000USD38,521,000USD54,837,000USD
    Cash And Short Term Investments235,882,000USD147,538,000USD38,521,000USD82,610,000USD
    Total Current Assets241,419,000USD150,993,000USD39,207,000USD83,833,000USD
    Total Current Liabilities11,712,000USD10,420,000USD8,037,000USD8,253,000USD
    Net Debt-49,774,000USD-28,039,000USD-28,044,000USD-54,837,000USD
    Short Term Debt1,269,000USD1,072,000USD728,000USD—
    Short Long Term Debt Total8,677,000USD9,749,000USD10,477,000USD—
    Long Term Investments74,420,000USD20,505,000USD0USD—
    Short Term Investments177,431,000USD109,750,000USD0USD27,773,000USD
    Accounts Payable769,000USD1,186,000USD719,000USD557,000USD
    Property Plant Equipment Net9,151,000USD10,298,000USD11,732,000USD2,574,000USD
    Property Plant Equipment Gross11,273,000USD11,869,000USD12,646,000USD2,918,000USD
    Accumulated Other Comprehensive Income540,000USD368,000USD—-16,000USD
    Common Stock Shares Outstanding39,962,163shares44,124,394shares44,124,394shares44,124,394shares
    Non Current Assets Total84,534,000USD34,759,000USD12,738,000USD3,536,000USD
    Non Current Liabilities Total7,408,000USD339,045,000USD158,789,000USD149,040,000USD
    Non Currrent Assets Other963,000USD3,956,000USD1,006,000USD962,000USD
    Net Working Capital229,707,000USD140,573,000USD31,170,000USD75,580,000USD
    Unclassified Non Current Liabilities7,408,000USD339,045,000USD158,789,000USD149,040,000USD
    Unclassified Equity562,557,000USD16,995,000USD4,513,000USD2,223,000USD
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Net Income-26,779,000USD-20,440,000USD-20,278,000USD-18,068,000USD-16,482,000USD-15,848,000USD-25,441,000USD-8,552,000USD
    Depreciation154,000USD503,000USD100,000USD147,000USD159,000USD167,000USD169,000USD166,000USD
    Stock Based Compensation6,553,000USD3,826,000USD3,306,000USD2,840,000USD2,094,000USD1,064,000USD1,026,000USD971,000USD
    Other Non Cash Items6,842,000USD-213,000USD-257,000USD-676,000USD-206,000USD-300,000USD8,132,000USD-613,000USD
    Change In Working Capital-2,057,000USD-302,000USD1,899,000USD-2,396,000USD-1,853,000USD3,136,000USD-1,572,000USD-2,117,000USD
    Total Cash From Operating Activities-21,840,000USD-16,626,000USD-15,230,000USD-18,153,000USD-16,288,000USD-11,781,000USD-17,686,000USD-10,145,000USD
    Capital Expenditures0USD-204,000USD-87,000USD0USD-86,000USD0USD0USD0USD
    Free Cash Flow-21,840,000USD-16,830,000USD-15,317,000USD-18,153,000USD-16,374,000USD-11,808,000USD-17,686,000USD-10,145,000USD
    Investments24,820,000USD22,792,000USD23,102,000USD-23,245,000USD-141,194,000USD15,228,000USD10,407,000USD-28,621,000USD
    Total Cashflows From Investing Activities24,820,000USD22,588,000USD23,102,000USD-23,245,000USD-141,194,000USD15,228,000USD10,407,000USD-28,621,000USD
    Total Cash From Financing Activities1,893,000USD1,659,000USD1,974,000USD-312,000USD202,389,000USD-1,408,000USD-996,000USD38,000USD
    Issuance Of Capital Stock0USD0USD0USD-318,000USD202,389,000USD0USD0USD0USD
    Change In Cash4,873,000USD7,621,000USD9,846,000USD-41,710,000USD44,907,000USD2,039,000USD-8,275,000USD-38,728,000USD
    Begin Period Cash Flow58,451,000USD51,793,000USD40,985,000USD83,657,000USD38,750,000USD36,711,000USD44,986,000USD83,714,000USD
    End Period Cash Flow63,324,000USD59,414,000USD50,831,000USD41,947,000USD83,657,000USD38,750,000USD36,711,000USD44,986,000USD
    Other Cashflows From Financing Activities1,893,000USD1,659,000USD1,974,000USD——-1,408,000USD-996,000USD—
    Unclassified Operating Cash Flow-6,553,000USD———————
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USD
    Net Income-75,268,000USD-61,688,000USD-47,263,000USD-40,240,000USD
    Depreciation-3,052,000USD668,000USD583,000USD122,000USD
    Stock Based Compensation12,066,000USD3,708,000USD2,259,000USD1,686,000USD
    Other Non Cash Items2,609,000USD7,600,000USD1,505,000USD-400,000USD
    Change In Working Capital-2,652,000USD-3,075,000USD-783,000USD2,764,000USD
    Total Cash From Operating Activities-66,297,000USD-52,787,000USD-43,699,000USD-36,068,000USD
    Capital Expenditures-377,000USD-27,000USD-1,116,000USD-1,874,000USD
    Free Cash Flow-66,674,000USD-52,814,000USD-44,815,000USD-37,942,000USD
    Investments-118,372,000USD-126,913,000USD27,352,000USD-29,263,000USD
    Total Cashflows From Investing Activities-118,749,000USD-126,913,000USD27,352,000USD-29,263,000USD
    Total Cash From Financing Activities205,710,000USD178,967,000USD31,000USD110,855,000USD
    Issuance Of Capital Stock202,071,000USD181,328,000USD0USD110,791,000USD
    Change In Cash20,664,000USD-733,000USD-16,316,000USD45,524,000USD
    Begin Period Cash Flow38,750,000USD39,483,000USD55,799,000USD10,275,000USD
    End Period Cash Flow59,414,000USD38,750,000USD39,483,000USD55,799,000USD
    Other Cashflows From Financing Activities205,710,000USD178,967,000USD31,000USD110,855,000USD
    Unclassified Financing Cash Flow-202,071,000USD-181,328,000USD—-110,791,000USD
    Unclassified Investing Cash Flow——1,116,000USD1,874,000USD
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Operating metrics

    No operating metrics are currently published for this company.

    Revenue breakdown

    No revenue breakdown is currently published for this company.

    Periods follow company fiscal calendars. Quarterly, annual and year-to-date amounts are shown separately. Missing values are not zero. Data may be delayed, incomplete or corrected; follow the disclosure links to verify figures.