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    Septerna, Inc.

    Company overview

    Market capitalization
    $1.85B
    Employees
    130
    Latest publication
    2026-09-29
    About Septerna, Inc.

    Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women's health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

    Company website

    Financial statements

    Income Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ2 20262026-06-30 · USDQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USD
    Total Revenue26,746,000USD26,523,000USD24,118,000USD21,495,000USD119,000USD219,000USD212,000USD176,000USD
    Research Development35,132,000USD29,114,000USD31,861,000USD24,264,000USD22,188,000USD19,271,000USD19,317,000USD17,832,000USD
    Total Operating Expenses43,582,000USD39,402,000USD40,141,000USD18,881,000USD29,097,000USD26,129,000USD24,930,000USD22,726,000USD
    Income Tax Expense973,000USD337,000USD12,000USD———-160,000USD-136,000USD
    Net Income-13,034,000USD-8,637,000USD-10,738,000USD8,173,000USD-24,838,000USD-21,476,000USD-20,668,000USD-20,523,000USD
    Cost Of Revenue—421,000USD401,000USD—————
    Gross Profit—26,102,000USD24,118,000USD21,495,000USD119,000USD219,000USD212,000USD176,000USD
    Selling General Administrative—10,288,000USD8,280,000USD7,117,000USD6,909,000USD6,858,000USD5,613,000USD4,894,000USD
    Operating Income—-13,300,000USD-16,023,000USD2,614,000USD-28,978,000USD-25,910,000USD-24,718,000USD-22,550,000USD
    Interest Income—5,031,000USD5,338,000USD5,565,000USD4,165,000USD4,462,000USD3,908,000USD1,900,000USD
    Net Interest Income—5,031,000USD5,338,000USD5,565,000USD4,165,000USD4,462,000USD3,908,000USD1,900,000USD
    Income Before Tax—-8,300,000USD-10,726,000USD8,173,000USD-24,838,000USD-21,476,000USD-20,828,000USD-20,659,000USD
    Tax Provision—337,000USD12,000USD0USD0USD0USD-160,000USD-136,000USD
    Net Income From Continuing Ops—-8,637,000USD-10,738,000USD8,173,000USD-24,838,000USD-21,476,000USD-20,668,000USD-20,523,000USD
    Ebit—-13,300,000USD-16,023,000USD-9,886,000USD-28,978,000USD-25,910,000USD-24,718,000USD-22,550,000USD
    Ebitda—-12,879,000USD-15,622,000USD-9,485,000USD-28,573,000USD-25,513,000USD-24,330,000USD-22,186,000USD
    Depreciation And Amortization—421,000USD401,000USD401,000USD405,000USD397,000USD388,000USD364,000USD
    Reconciled Depreciation—421,000USD401,000USD401,000USD405,000USD397,000USD388,000USD364,000USD
    Total Other Income Expense Net—5,000,000USD5,297,000USD5,559,000USD4,140,000USD4,434,000USD3,890,000USD1,891,000USD
    Unclassified Operating Expenses———-12,500,000USD————
    Source0001193125-26-342328PreliminaryLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Income Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USD
    Total Revenue45,951,000USD1,075,000USD151,000USD0USD
    Cost Of Revenue1,604,000USD———
    Gross Profit45,951,000USD1,075,000USD151,000USD—
    Research Development97,584,000USD65,337,000USD35,979,000USD22,044,000USD
    Selling General Administrative29,164,000USD16,561,000USD9,722,000USD5,923,000USD
    Total Operating Expenses126,748,000USD81,898,000USD-1,924,000USD27,967,000USD
    Operating Income-80,797,000USD-80,823,000USD2,075,000USD-27,967,000USD
    Interest Income19,530,000USD8,617,000USD2,786,000USD291,000USD
    Net Interest Income19,530,000USD8,617,000USD2,786,000USD291,000USD
    Income Before Tax-48,867,000USD-72,296,000USD4,871,000USD-27,676,000USD
    Income Tax Expense12,000USD-498,000USD691,000USD—
    Tax Provision12,000USD-498,000USD691,000USD0USD
    Net Income-48,879,000USD-71,798,000USD4,180,000USD-27,676,000USD
    Net Income From Continuing Ops-48,879,000USD-71,798,000USD4,180,000USD-27,676,000USD
    Ebit-80,797,000USD-80,823,000USD-45,550,000USD-27,967,000USD
    Ebitda-79,193,000USD-79,422,000USD-44,702,000USD-27,390,000USD
    Depreciation And Amortization1,604,000USD1,401,000USD848,000USD577,000USD
    Reconciled Depreciation1,604,000USD1,401,000USD848,000USD577,000USD
    Total Other Income Expense Net31,930,000USD8,527,000USD2,796,000USD291,000USD
    Unclassified Operating Expenses——-47,625,000USD—
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ2 20262026-06-30 · USDQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USD
    Total Assets566,737,000USD569,688,000USD596,187,000USD606,653,000USD415,231,000USD434,020,000USD456,554,000USD174,281,000USD
    Total Liabilities180,016,000USD———————
    Other Current Assets—9,815,000USD9,519,000USD8,690,000USD5,014,000USD5,138,000USD4,777,000USD2,545,000USD
    Total Liab—191,230,000USD214,261,000USD217,922,000USD37,674,000USD33,754,000USD36,507,000USD261,689,000USD
    Total Stockholder Equity—378,458,000USD381,926,000USD388,731,000USD377,557,000USD400,266,000USD420,047,000USD-87,408,000USD
    Other Current Liab—8,629,000USD12,167,000USD69,436,000USD6,557,000USD4,352,000USD7,798,000USD5,787,000USD
    Common Stock—45,000USD45,000USD45,000USD45,000USD44,000USD44,000USD3,000USD
    Capital Stock—45,000USD45,000USD45,000USD45,000USD44,000USD44,000USD3,000USD
    Retained Earnings—-175,890,000USD-167,253,000USD-156,515,000USD-164,688,000USD-139,850,000USD-118,374,000USD-97,706,000USD
    Cash—71,605,000USD120,722,000USD319,989,000USD189,311,000USD210,045,000USD238,196,000USD88,242,000USD
    Cash And Short Term Investments—347,401,000USD391,089,000USD474,346,000USD326,561,000USD336,005,000USD350,923,000USD130,533,000USD
    Total Current Assets—368,058,000USD410,964,000USD491,681,000USD334,141,000USD342,469,000USD356,824,000USD133,411,000USD
    Total Current Liabilities—78,165,000USD86,931,000USD75,282,000USD15,127,000USD10,638,000USD12,849,000USD13,231,000USD
    Current Deferred Revenue—59,763,000USD62,269,000USD—————
    Net Debt—-48,515,000USD-97,097,000USD-295,879,000USD-164,740,000USD-185,019,000USD-212,720,000USD-63,016,000USD
    Short Term Debt—2,309,000USD2,212,000USD2,117,000USD2,026,000USD1,937,000USD1,851,000USD1,116,000USD
    Short Long Term Debt Total—23,090,000USD23,625,000USD24,110,000USD24,571,000USD25,026,000USD25,476,000USD25,226,000USD
    Long Term Investments—174,691,000USD157,569,000USD87,212,000USD52,633,000USD62,242,000USD69,866,000USD6,979,000USD
    Short Term Investments—275,796,000USD270,367,000USD154,357,000USD137,250,000USD125,960,000USD112,727,000USD42,291,000USD
    Net Receivables—10,842,000USD10,356,000USD8,645,000USD2,566,000USD1,326,000USD1,124,000USD333,000USD
    Accounts Payable—7,464,000USD10,283,000USD3,729,000USD6,544,000USD4,349,000USD3,200,000USD6,128,000USD
    Property Plant Equipment Net—25,261,000USD25,933,000USD26,354,000USD27,252,000USD28,127,000USD28,692,000USD29,507,000USD
    Property Plant Equipment Gross—30,034,000USD30,285,000USD30,414,000USD30,968,000USD31,453,000USD31,621,000USD32,048,000USD
    Accumulated Other Comprehensive Income—-569,000USD617,000USD374,999USD176,000USD198,000USD56,000USD176,000USD
    Common Stock Shares Outstanding—44,758,800shares44,258,338shares45,602,099shares44,165,168shares43,937,410shares32,383,314shares42,002,794shares
    Non Current Assets Total—201,630,000USD185,223,000USD114,972,000USD81,090,000USD91,551,000USD99,730,000USD40,870,000USD
    Non Current Liabilities Total—113,065,000USD127,330,000USD142,640,000USD22,547,000USD23,116,000USD23,658,000USD248,458,000USD
    Non Current Liabilities Other—100,000USD——2,000USD27,000USD33,000USD191,000USD
    Non Currrent Assets Other—176,369,000USD816,000USD1,406,000USD1,205,000USD1,182,000USD1,172,000USD4,384,000USD
    Net Working Capital—289,893,000USD324,033,000USD416,399,000USD319,014,000USD331,831,000USD343,975,000USD120,180,000USD
    Unclassified Non Current Assets—-174,691,000USD——————
    Unclassified Non Current Liabilities—112,965,000USD127,330,000USD142,640,000USD22,545,000USD23,089,000USD23,625,000USD248,267,000USD
    Unclassified Equity—554,827,000USD548,472,000USD544,781,001USD541,979,000USD539,830,000USD538,277,000USD10,116,000USD
    Source0001193125-26-342328PreliminaryLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USD
    Total Assets596,187,000USD456,554,000USD130,867,000USD36,119,000USD
    Other Current Assets9,519,000USD4,777,000USD1,419,000USD1,283,000USD
    Total Liab214,261,000USD36,507,000USD169,241,000USD80,320,000USD
    Total Stockholder Equity381,926,000USD420,047,000USD-38,374,000USD-44,201,000USD
    Other Current Liab12,167,000USD7,798,000USD4,077,000USD1,762,000USD
    Common Stock45,000USD44,000USD3,000USD3,000USD
    Capital Stock45,000USD44,000USD3,000USD3,000USD
    Retained Earnings-167,253,000USD-118,374,000USD-46,576,000USD-50,756,000USD
    Cash120,722,000USD238,196,000USD88,483,000USD30,607,000USD
    Cash And Short Term Investments391,089,000USD350,923,000USD88,483,000USD30,607,000USD
    Total Current Assets410,964,000USD356,824,000USD112,678,000USD31,890,000USD
    Total Current Liabilities86,931,000USD12,849,000USD6,914,000USD5,543,000USD
    Current Deferred Revenue62,269,000USD———
    Net Debt-97,097,000USD-212,720,000USD-75,917,000USD-29,897,000USD
    Short Term Debt2,212,000USD1,851,000USD—710,000USD
    Short Long Term Debt Total23,625,000USD25,476,000USD12,566,000USD710,000USD
    Long Term Investments157,569,000USD69,866,000USD0USD—
    Short Term Investments270,367,000USD112,727,000USD0USD—
    Net Receivables10,356,000USD1,124,000USD22,776,000USD0USD
    Accounts Payable10,283,000USD3,200,000USD2,637,000USD3,071,000USD
    Property Plant Equipment Net25,933,000USD28,692,000USD17,187,000USD3,105,000USD
    Property Plant Equipment Gross30,285,000USD31,621,000USD18,809,000USD3,903,000USD
    Accumulated Other Comprehensive Income617,000USD56,000USD——
    Common Stock Shares Outstanding44,258,338shares37,193,054shares19,495,760shares19,495,760shares
    Non Current Assets Total185,223,000USD99,730,000USD18,189,000USD4,229,000USD
    Non Current Liabilities Total127,330,000USD23,658,000USD162,327,000USD74,777,000USD
    Non Currrent Assets Other159,290,000USD1,172,000USD1,002,000USD1,124,000USD
    Net Working Capital324,033,000USD343,975,000USD105,764,000USD26,347,000USD
    Unclassified Non Current Assets-157,569,000USD———
    Unclassified Non Current Liabilities127,330,000USD23,625,000USD161,781,000USD74,694,000USD
    Unclassified Equity548,472,000USD538,277,000USD8,196,000USD6,549,000USD
    Non Current Liabilities Other—33,000USD546,000USD83,000USD
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Net Income-8,637,000USD-10,738,000USD8,173,000USD-24,838,000USD-21,476,000USD-20,668,000USD-20,523,000USD-16,440,999USD
    Depreciation421,000USD401,000USD400,000USD400,000USD397,000USD388,000USD364,000USD333,000USD
    Stock Based Compensation6,015,000USD2,656,000USD2,532,000USD1,806,000USD1,482,000USD1,264,000USD683,000USD628,000USD
    Other Non Cash Items5,829,000USD-318,000USD-10,034,000USD1,367,000USD-460,000USD-323,000USD83,000USD701,999USD
    Change To Account Receivables-486,000USD-1,711,000USD-8,494,000USD99,000USD-79,000USD40,000USD-10,000USD190,000USD
    Change In Working Capital-23,246,000USD-6,989,000USD170,268,000USD2,784,000USD-3,286,000USD-1,466,000USD2,715,000USD2,528,000USD
    Total Cash From Operating Activities-25,633,000USD-14,988,000USD168,807,000USD-20,287,000USD-23,343,000USD-20,958,000USD-16,814,000USD-12,987,000USD
    Capital Expenditures-832,000USD-65,000USD-13,000USD-58,000USD-382,000USD-612,000USD-578,000USD-149,000USD
    Free Cash Flow-26,465,000USD-15,053,000USD168,794,000USD-20,345,000USD-23,725,000USD-21,570,000USD-17,392,000USD-13,136,000USD
    Investments-22,985,000USD-185,235,000USD-38,392,000USD-786,000USD-4,874,000USD-133,239,000USD-24,794,000USD-12,133,000USD
    Total Cashflows From Investing Activities-23,817,000USD-185,300,000USD-38,392,000USD-786,000USD-4,874,000USD-133,239,000USD-24,794,000USD-12,133,000USD
    Total Cash From Financing Activities333,000USD1,021,000USD263,000USD339,000USD66,000USD304,151,000USD-1,322,000USD74,952,000USD
    Change In Cash-49,117,000USD-199,267,000USD130,678,000USD-20,734,000USD-28,151,000USD149,954,000USD-42,930,000USD131,172,000USD
    Begin Period Cash Flow120,722,000USD320,894,000USD189,311,000USD210,045,000USD238,196,000USD89,147,000USD132,077,000USD82,245,000USD
    End Period Cash Flow71,605,000USD121,627,000USD319,989,000USD189,311,000USD210,045,000USD239,101,000USD89,147,000USD131,172,000USD
    Other Cashflows From Financing Activities333,000USD1,021,000USD263,000USD339,000USD66,000USD1,363,000USD-1,322,000USD74,952,000USD
    Unclassified Operating Cash Flow-6,015,000USD—-2,532,000USD-1,806,000USD————
    Sale Purchase Of Stock—0USD-1,000USD—0USD0USD——
    Issuance Of Capital Stock—0USD0USD——302,788,000USD-58,000USD—
    Other Cashflows From Investing Activities——12,500,000USD——-1,654,000USD-721,000USD—
    Unclassified Investing Cash Flow——-12,487,000USD——2,266,000USD1,299,000USD—
    Unclassified Financing Cash Flow—————302,788,000USD——
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USD
    Net Income-48,879,000USD-71,798,000USD4,180,000USD-27,676,000USD
    Depreciation1,604,000USD1,401,000USD848,000USD577,000USD
    Stock Based Compensation8,476,000USD3,152,000USD1,620,000USD1,520,000USD
    Other Non Cash Items-13,789,000USD18,000USD-46,788,000USD530,000USD
    Change To Account Receivables-10,185,000USD-20,000USD-151,000USD0USD
    Change In Working Capital162,777,000USD248,000USD926,000USD1,746,000USD
    Total Cash From Operating Activities110,189,000USD-67,470,000USD-38,723,000USD-23,303,000USD
    Capital Expenditures-518,000USD-2,103,000USD-2,878,000USD-1,289,000USD
    Free Cash Flow109,671,000USD-69,573,000USD-41,601,000USD-24,592,000USD
    Investments-241,334,000USD-160,598,000USD22,122,000USD-1,289,000USD
    Total Cashflows From Investing Activities-229,352,000USD-160,598,000USD22,122,000USD-1,289,000USD
    Total Cash From Financing Activities1,689,000USD377,781,000USD74,520,000USD30,051,000USD
    Sale Purchase Of Stock-1,000USD-1,000USD-1,000USD—
    Issuance Of Capital Stock0USD377,730,000USD74,521,000USD29,969,000USD
    Change In Cash-117,474,000USD149,713,000USD57,919,000USD5,459,000USD
    Begin Period Cash Flow239,101,000USD89,388,000USD31,469,000USD26,010,000USD
    End Period Cash Flow121,627,000USD239,101,000USD89,388,000USD31,469,000USD
    Other Cashflows From Investing Activities12,500,000USD22,625,000USD25,000,000USD—
    Other Cashflows From Financing Activities1,689,000USD74,994,000USD74,521,000USD30,051,000USD
    Unclassified Investing Cash Flow—-20,522,000USD-22,122,000USD1,289,000USD
    Unclassified Financing Cash Flow—302,788,000USD—-29,969,000USD
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Operating metrics

    No operating metrics are currently published for this company.

    Revenue breakdown

    No revenue breakdown is currently published for this company.

    Periods follow company fiscal calendars. Quarterly, annual and year-to-date amounts are shown separately. Missing values are not zero. Data may be delayed, incomplete or corrected; follow the disclosure links to verify figures.