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    PRME

    Prime Medicine, Inc.

    Company overview

    Market capitalization
    $521.46M
    Employees
    146
    Latest publication
    2026-09-29
    About Prime Medicine, Inc.

    Prime Medicine, Inc., a biotechnology company, engages in delivering genetic medicines to address the spectrum of diseases by deploying gene editing technology in the United States. Its lead therapeutic product candidate is PM359 for Chronic Granulomatous Disease, which is in Phase 1/2 clinical trial; PM577 for Wilson Disease, that is in preclinical studies; and PM647 to treat genetic disorder caused by mutations in the SERPINA1 gene, resulting in production of misfolded Z-AAT protein that accumulates in the liver and leads to hepatocellular injury, cirrhosis, and increased risk of hepatocellular carcinoma. The company also provides vivo programs targeting diseases of the liver, and Cystic Fibrosis programs. In addition, it offers Prime Editing technology comprising a programmable DNA binding domains, such as Cas domains, are typically modified such that they do not cause a double-stranded break in the DNA, as well as a RT domain that copies the edited DNA sequence directly into the target genomic site where the edit is made; and pegRNA which contains a search sequence, also known as a spacer, which provides a target genomic address for the Prime Editor. The company has a research collaboration and license agreement with BMS; Cystic Fibrosis Foundation; Broad Institute; and Beam. Prime Medicine, Inc. was incorporated in 2019 and is headquartered in Cambridge, Massachusetts.

    Company website

    Financial statements

    Income Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Total Revenue856,000USD838,000USD1,225,000USD1,115,000USD1,454,000USD2,983,000USD209,000USD0USD
    Research Development34,105,000USD34,709,000USD43,990,000USD41,375,000USD40,562,000USD155,289,000USD40,340,000USD43,071,000USD
    Total Operating Expenses51,510,000USD49,446,000USD55,198,000USD54,492,000USD53,846,000USD205,450,000USD54,441,000USD55,672,000USD
    Net Income-49,122,000USD-46,079,000USD-50,582,000USD-52,591,000USD-51,890,000USD-195,882,000USD-52,518,000USD-55,327,000USD
    Cost Of Revenue—1,876,000USD——————
    Gross Profit—838,000USD——————
    Selling General Administrative—14,737,000USD11,208,000USD13,117,000USD13,284,000USD—14,101,000USD12,601,000USD
    Operating Income—-48,608,000USD-53,973,000USD-53,377,000USD-52,392,000USD—-54,232,000USD-55,672,000USD
    Interest Income—1,083,000USD1,141,000USD743,000USD1,182,000USD—697,000USD611,000USD
    Net Interest Income—1,083,000USD——————
    Income Before Tax—-46,079,000USD—-52,591,000USD-51,890,000USD—-52,518,000USD-55,461,000USD
    Net Income From Continuing Ops—-46,079,000USD——————
    Ebit—-46,079,000USD——————
    Ebitda—-44,203,000USD——————
    Depreciation And Amortization—1,876,000USD——————
    Reconciled Depreciation—1,876,000USD——————
    Total Other Income Expense Net—2,529,000USD3,391,000USD786,000USD502,000USD—1,714,000USD211,000USD
    General And Administrative Expenses——11,208,000USD13,117,000USD13,284,000USD—14,101,000USD12,601,000USD
    Net Income Applicable To Common Shares——-50,582,000USD-52,591,000USD-51,890,000USD—-52,518,000USD-55,327,000USD
    Income Tax Expense———0USD0USD—0USD-134,000USD
    SourceDisclosurePreliminaryLegacy providerLegacyDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosurePreliminaryDisclosureDeterministicFinalDisclosureDeterministicFinal

    Income Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USDFY 20212021-12-31 · USDFY 20202020-12-31 · USDFY 20192019-12-31 · USD
    Total Revenue4,632,000USD2,983,000USD0USD0USD0USD5,210,000USD—
    Research Development160,636,000USD155,289,000USD147,905,000USD86,725,000USD70,550,000USD2,980,000USD920,000USD
    Selling General Administrative52,346,000USD50,161,000USD43,387,000USD29,819,000USD13,924,000USD3,162,000USD3,756,000USD
    General And Administrative Expenses52,346,000USD50,161,000USD—29,819,000USD———
    Total Operating Expenses212,982,000USD205,450,000USD204,792,000USD116,544,000USD84,474,000USD3,162,000USD2,172,000USD
    Operating Income-208,350,000USD-202,467,000USD-204,792,000USD-116,544,000USD-84,474,000USD-932,000USD-2,172,000USD
    Total Other Income Expense Net7,208,000USD6,585,000USD6,380,000USD-6,225,000USD-81,379,000USD-611,000USD3,991,000USD
    Interest Income4,149,000USD3,522,000USD2,811,000USD————
    Income Before Tax-201,142,000USD-195,882,000USD-198,412,000USD-122,769,000USD-165,853,000USD-1,543,000USD-2,525,000USD
    Income Tax Expense0USD0USD-279,000USD-948,000USD-486,000USD1,867,000USD4,000USD
    Net Income-201,142,000USD-195,882,000USD-198,133,000USD-121,821,000USD-165,367,000USD-3,410,000USD-2,529,000USD
    Net Income Applicable To Common Shares-201,142,000USD-195,882,000USD—-142,014,000USD-184,119,000USD-5,055,000USD-8,382,000USD
    Cost Of Revenue——4,653,000USD—4,861,000USD2,980,000USD2,760,000USD
    Gross Profit——-4,653,000USD—-4,861,000USD2,230,000USD-2,760,000USD
    Selling And Marketing Expenses——4,653,000USD————
    Unclassified Operating Expenses——8,847,000USD——-2,980,000USD-2,504,000USD
    Net Interest Income——2,811,000USD————
    Tax Provision——-465,000USD—-486,000USD1,867,000USD—
    Net Income From Continuing Ops——-171,773,000USD—-165,367,000USD-3,410,000USD—
    Ebit——-191,292,000USD—-165,853,000USD-932,000USD-8,688,000USD
    Ebitda——-186,639,000USD—-165,285,000USD-889,000USD-2,172,000USD
    Depreciation And Amortization——4,653,000USD—568,000USD43,000USD6,516,000USD
    Reconciled Depreciation——4,276,000USD—568,000USD43,000USD—
    Interest Expense————81,770,000USD10,256,000USD—
    SourceDisclosureDeterministicFinalDisclosureDeterministicFinalLegacy providerLegacyDisclosureDeterministicFinalLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Total Assets294,730,000USD342,733,000USD385,012,000USD279,009,000USD328,163,000USD297,508,000USD332,784,000USD259,705,000USD
    Cash And Equivalents64,106,000USD63,032,000USD71,396,000USD53,804,000USD91,877,000USD182,476,000USD117,977,000USD55,600,000USD
    Cash And Short Term Investments135,500,000USD177,700,000USD213,300,000USD101,800,000USD144,300,000USD190,400,000USD175,500,000USD162,900,000USD
    Total Current Assets137,889,000USD181,293,000USD231,406,000USD121,287,000USD163,765,000USD211,886,000USD246,071,000USD170,803,000USD
    Other Current Assets421,000USD674,000USD15,626,000USD16,385,000USD16,544,000USD14,667,000USD9,538,000USD3,736,000USD
    Other Non Current Assets1,000,000USD1,000,000USD———0USD0USD0USD
    Total Liabilities218,030,000USD221,865,000USD223,191,000USD218,149,000USD221,239,000USD144,359,000USD143,280,000USD63,116,000USD
    Total Current Liabilities36,289,000USD37,448,000USD35,019,000USD34,109,000USD34,288,000USD37,961,000USD37,877,000USD20,749,000USD
    Other Current Liabilities8,098,000USD12,600,000USD11,000,000USD12,158,000USD9,191,000USD15,904,000USD18,684,000USD10,895,000USD
    Total Stockholder Equity76,700,000USD120,868,000USD161,821,000USD60,860,000USD106,924,000USD153,149,000USD189,504,000USD196,589,000USD
    Total Equity Including Noncontrolling Interest76,700,000USD120,868,000USD161,821,000USD60,860,000USD106,924,000USD153,149,000USD189,504,000USD196,589,000USD
    Deferred Revenue7,320,000USD7,824,000USD6,951,000USD8,315,000USD8,214,000USD7,092,000USD9,280,000USD—
    Deferred Revenue Non Current57,775,000USD58,127,000USD59,751,000USD59,562,000USD60,658,000USD63,218,000USD62,639,000USD—
    Property Plant Equipment Net142,150,000USD146,749,000USD139,915,000USD144,031,000USD150,336,000USD71,560,000USD72,651,000USD75,406,000USD
    Accounts Payable12,325,000USD8,887,000USD9,354,000USD6,378,000USD10,025,000USD11,351,000USD5,429,000USD4,638,000USD
    Short Term Debt8,546,000USD8,137,000USD7,714,000USD7,258,000USD6,858,000USD3,614,000USD4,484,000USD5,216,000USD
    Common Stock2,000USD2,000USD2,000USD2,000USD2,000USD2,000USD2,000USD2,000USD
    Retained Earnings-937,476,000USD-888,354,000USD-842,275,000USD-791,693,000USD-739,102,000USD-687,212,000USD-644,936,000USD-592,418,000USD
    Accumulated Other Comprehensive Income-1,000USD82,000USD33,000USD-10,000USD-15,000USD1,000USD21,000USD-71,000USD
    SourceDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinal

    Balance sheet Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USDFY 20212021-12-31 · USDFY 20202020-12-31 · USDFY 20192019-12-31 · USD
    Total Assets342,733,000USD297,508,000USD193,851,000USD360,314,000USD301,856,000USD54,783,000USD8,697,000USD
    Cash And Equivalents63,032,000USD182,476,000USD41,574,000USD187,620,000USD———
    Cash And Short Term Investments177,700,000USD190,400,000USD121,700,000USD293,900,000USD269,620,000USD53,328,000USD8,647,000USD
    Total Current Assets181,293,000USD211,886,000USD142,976,000USD296,618,000USD270,579,000USD53,402,000USD8,697,000USD
    Other Current Assets674,000USD14,667,000USD2,254,000USD2,697,000USD959,000USD74,000USD50,000USD
    Other Non Current Assets1,000,000USD0USD779,000USD1,646,000USD———
    Total Liabilities221,865,000USD144,359,000USD60,780,000USD44,044,000USD———
    Total Current Liabilities37,448,000USD37,961,000USD56,423,000USD26,714,000USD57,983,000USD19,442,000USD7,308,000USD
    Other Current Liabilities12,600,000USD15,904,000USD14,110,000USD10,688,000USD———
    Total Stockholder Equity120,868,000USD153,149,000USD133,071,000USD316,270,000USD239,560,000USD33,474,000USD1,389,000USD
    Total Equity Including Noncontrolling Interest120,868,000USD153,149,000USD133,071,000USD316,270,000USD———
    Deferred Revenue7,824,000USD7,092,000USD—————
    Deferred Revenue Non Current58,127,000USD63,218,000USD—————
    Property Plant Equipment Net146,749,000USD71,560,000USD36,600,000USD48,554,000USD15,678,000USD596,000USD—
    Accounts Payable8,887,000USD11,351,000USD19,537,000USD4,332,000USD1,435,000USD250,000USD—
    Short Term Debt8,137,000USD3,614,000USD9,276,000USD11,694,000USD7,336,000USD17,515,000USD—
    Common Stock2,000USD2,000USD2,000USD2,000USD1,000USD1,000USD1,000USD
    Retained Earnings-888,354,000USD-687,212,000USD-491,330,000USD-293,197,000USD-171,376,000USD-6,009,000USD-2,599,000USD
    Accumulated Other Comprehensive Income82,000USD1,000USD-15,000USD-384,000USD-27,000USD-1,000USD0USD
    Short Term Investments——5,452,000USD7,834,000USD84,200,000USD16,353,000USD—
    Total Liab————62,296,000USD21,309,000USD7,308,000USD
    Other Current Liab————49,212,000USD19,192,000USD7,308,000USD
    Capital Stock————395,800,000USD31,136,000USD—
    Other Liab————1,243,000USD1,867,000USD—
    Other Assets————15,599,000USD785,000USD—
    Cash————185,420,000USD36,975,000USD8,647,000USD
    Current Deferred Revenue————36,913,000USD-17,515USD—
    Net Debt————-175,014,000USD-36,975,000USD-8,647,000USD
    Short Long Term Debt Total————10,406,000USD17,515,000USD—
    Property Plant Equipment Gross————16,289,000USD639,000USD—
    Common Stock Shares Outstanding————95,730,151shares95,730,151shares95,730,151shares
    Non Current Assets Total————31,277,000USD1,381,000USD—
    Non Current Liabilities Total————4,313,000USD1,867,000USD—
    Non Currrent Assets Other————15,599,000USD785,000USD—
    Net Working Capital————212,596,000USD33,960,000USD—
    Net Tangible Assets————-156,240,000USD2,338,000USD-2,598,000USD
    Unclassified Non Current Assets————-15,599,000USD——
    Unclassified Current Liabilities————-36,913,000USD-17,515,000USD—
    Unclassified Non Current Liabilities————3,070,000USD——
    Unclassified Equity————15,162,000USD8,347,000USD3,987,000USD
    SourceDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Depreciation1,856,000USD514,000USD1,881,000USD1,453,000USD1,700,000USD1,717,000USD1,558,000USD1,538,000USD
    Stock Based Compensation4,644,000USD4,515,000USD12,747,000USD6,325,000USD5,681,000USD5,941,000USD6,827,000USD8,091,000USD
    Change To Account Receivables0USD—120,000USD-103,000USD-17,000USD———
    Change To Liabilities-950,000USD———-4,771,000USD———
    Change In Working Capital4,773,000USD1,156,000USD609,000USD548,000USD1,078,000USD48,860,000USD3,576,000USD8,751,000USD
    Operating Cash Flow-42,710,000USD———-48,857,000USD———
    Capital Expenditures-214,000USD-290,000USD-247,000USD-1,572,000USD-2,422,000USD-1,791,000USD-1,277,000USD-1,902,000USD
    Unclassified Investing Cash Flow43,605,000USD——1,572,000USD-45,320,000USD1,515,000USD—1,902,000USD
    Investing Cash Flow43,391,000USD———-47,742,000USD———
    Financing Cash Flow393,000USD———6,000,000USD———
    Change In Cash1,074,000USD-8,364,000USD17,592,000USD-38,444,000USD-90,599,000USD64,499,000USD62,943,000USD-38,562,000USD
    End Cash Flow77,797,000USD———105,939,000USD———
    Net Income—-46,079,000USD-50,582,000USD-52,591,000USD—-42,276,000USD-52,518,000USD-55,327,000USD
    Other Non Cash Items—2,638,000USD306,000USD2,853,000USD—2,003,000USD14,645,000USD-8,410,000USD
    Total Cash From Operating Activities—-37,256,000USD-35,039,000USD-41,412,000USD—16,245,000USD-25,912,000USD-45,491,000USD
    Free Cash Flow—-37,546,000USD-35,286,000USD-42,984,000USD—14,454,000USD-27,189,000USD-47,393,000USD
    Investments—28,620,000USD-92,122,000USD2,771,000USD—48,253,000USD50,342,000USD6,894,000USD
    Total Cashflows From Investing Activities—28,330,000USD-92,122,000USD2,771,000USD—48,253,000USD50,342,000USD6,894,000USD
    Total Cash From Financing Activities—562,000USD144,753,000USD197,000USD—1,000USD38,513,000USD35,000USD
    Issuance Of Capital Stock—10,000USD138,380,000USD0USD—0USD38,081,000USD0USD
    Begin Period Cash Flow—71,396,000USD53,804,000USD105,939,000USD—117,977,000USD69,096,000USD94,162,000USD
    End Period Cash Flow—63,032,000USD71,396,000USD67,495,000USD—182,476,000USD132,039,000USD55,600,000USD
    Other Cashflows From Financing Activities—145,512,000USD6,000,000USD197,000USD—170,137,000USD432,000USD-151,291,000USD
    Unclassified Financing Cash Flow—-144,960,000USD———-170,136,000USD—151,326,000USD
    Deferred Income Tax————0USD———
    Other Cashflows From Investing Activities—————276,000USD724,000USD—
    SourceDisclosureDeterministicFinalLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyDisclosureDeterministicFinalLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USDFY 20212021-12-31 · USDFY 20202020-12-31 · USDFY 20192019-12-31 · USD
    Depreciation7,321,000USD6,128,000USD4,653,000USD2,224,000USD568,000USD43,000USD43,000USD
    Stock Based Compensation29,268,000USD26,068,000USD13,910,000USD6,459,000USD1,746,000USD391,000USD—
    Change To Liabilities-164,000USD-3,414,000USD10,898,000USD-23,415,000USD1,185,000USD250,000USD0USD
    Change In Working Capital5,541,000USD-21,116,000USD-315,000USD720,000USD31,176,000USD164,000USD492,000USD
    Operating Cash Flow-162,564,000USD-122,865,000USD-165,412,000USD-131,827,000USD———
    Capital Expenditures-4,531,000USD-7,294,000USD-8,724,000USD-16,095,000USD-4,150,000USD-639,000USD-639,000USD
    Unclassified Investing Cash Flow-104,232,000USD75,751,000USD27,435,000USD-31,001,000USD—68,980,000USD68,980,000USD
    Investing Cash Flow-108,763,000USD68,457,000USD18,711,000USD-47,096,000USD———
    Financing Cash Flow151,512,000USD195,876,000USD655,000USD181,494,000USD———
    Change In Cash-119,815,000USD141,468,000USD-146,046,000USD2,571,000USD161,570,000USD28,328,000USD8,647,000USD
    End Cash Flow76,723,000USD196,538,000USD55,070,000USD201,116,000USD———
    Deferred Income Tax—0USD-279,000USD-964,000USD———
    Other Non Cash Items———0USD98,419,000USD-4,599,000USD703,000USD
    Net Income————-165,367,000USD-3,410,000USD-2,529,000USD
    Total Cash From Operating Activities————-34,082,000USD-5,544,000USD-1,334,000USD
    Free Cash Flow————-38,232,000USD-6,183,000USD-1,334,000USD
    Investments————-68,980,000USD-68,980,000USD-68,980,000USD
    Total Cashflows From Investing Activities————-73,626,000USD-1,062,000USD-1,062,000USD
    Total Cash From Financing Activities————269,278,000USD34,934,000USD9,981,000USD
    Issuance Of Capital Stock————270,364,000USD34,954,000USD—
    Begin Period Cash Flow————36,975,000USD8,647,000USD—
    End Period Cash Flow————198,545,000USD36,975,000USD8,647,000USD
    Other Cashflows From Investing Activities————-496,000USD-423,000USD-423,000USD
    Other Cashflows From Financing Activities————-1,086,000USD34,934,000USD9,981,000USD
    Unclassified Operating Cash Flow—————1,867,000USD—
    Unclassified Financing Cash Flow—————-34,954,000USD—
    SourceDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow YTD

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USDQ3 20232023-09-30 · USDQ2 20232023-06-30 · USDQ3 20222022-09-30 · USD
    Depreciation5,445,000USD3,564,000USD4,411,000USD2,853,000USD3,406,000USD2,170,000USD1,354,000USD
    Stock Based Compensation24,753,000USD12,006,000USD20,127,000USD13,300,000USD9,481,000USD5,264,000USD3,885,000USD
    Change To Account Receivables0USD-120,000USD-55,000,000USD————
    Change To Liabilities-1,183,000USD-3,151,000USD-5,730,000USD-13,169,000USD6,106,000USD-2,334,000USD-27,934,000USD
    Change In Working Capital3,526,000USD-929,000USD-72,183,000USD-11,749,000USD-2,179,000USD-4,195,000USD947,000USD
    Operating Cash Flow-125,308,000USD-90,269,000USD-139,110,000USD-113,198,000USD-121,548,000USD-82,382,000USD-101,114,000USD
    Capital Expenditures-4,241,000USD-3,994,000USD-5,503,000USD-4,226,000USD-6,884,000USD-3,975,000USD-11,281,000USD
    Unclassified Investing Cash Flow-132,852,000USD-40,977,000USD25,707,000USD-25,912,000USD-15,690,000USD19,171,000USD-22,128,000USD
    Investing Cash Flow-137,093,000USD-44,971,000USD20,204,000USD-30,138,000USD-22,574,000USD15,196,000USD-33,409,000USD
    Financing Cash Flow150,950,000USD6,197,000USD195,875,000USD157,362,000USD461,000USD143,000USD-2,579,000USD
    Change In Cash-111,451,000USD-129,043,000USD76,969,000USD14,026,000USD-143,661,000USD-67,043,000USD-137,102,000USD
    End Cash Flow85,087,000USD67,495,000USD132,039,000USD69,096,000USD57,455,000USD134,073,000USD61,443,000USD
    Deferred Income Tax—0USD0USD0USD-279,000USD-171,000USD-762,000USD
    SourceDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinalDisclosureDeterministicFinal

    Operating metrics

    No operating metrics are currently published for this company.

    Revenue breakdown

    No revenue breakdown is currently published for this company.

    Periods follow company fiscal calendars. Quarterly, annual and year-to-date amounts are shown separately. Missing values are not zero. Data may be delayed, incomplete or corrected; follow the disclosure links to verify figures.