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    Opus Genetics, Inc.

    Company overview

    Market capitalization
    $420.14M
    Employees
    27
    Latest publication
    2026-09-29
    About Opus Genetics, Inc.

    Opus Genetics, Inc., a clinical-stage biopharmaceutical company, develops gene therapies to restore vision and prevent blindness in patients with inherited retinal diseases (IRDs) and other types of therapies for additional ophthalmic disorders. It develops OPGx-LCA5, an early-onset retinal degeneration that is in Phase 1/2 clinical trial for the treatment of LCA5-associated IRD; and OPGx-BEST1 to treat BEST1-associated retinal disease. The company also develops various pre-clinical IRD programs, including OPGx-RHO, a gene therapy that targets autosomal dominant retinitis pigmentosa caused by RHO mutations; OPGx-RDH12 that is designed to restore protein expression and halt functional deterioration in patients with retinal dystrophy caused by mutations in the retinal dehydrogenase gene; OPGx-MERTK, an AAV vector for the treatment of MERTK IRD; OPGx-NMNAT1, a gene augmentation therapy designed to halt functional deterioration in pediatric patients with retinal degenerative disease caused by mutations in the nicotinamide mononucleotide adenylyltransferase 1 gene; and OPGx-CNGB1, an AAV gene therapy for retinitis pigmentosa due to mutations in the CNGB1 gene. In addition, it develops Phentolamine Ophthalmic Solution for reversal of mydriasis, as well as for the treatment of presbyopia and dim light or night vision disturbances and APX3330, a small-molecule inhibitor of Ref-1 for the treatment of diabetic retinopathy. Opus Genetics, Inc. was formerly known as Ocuphire Pharma, Inc. and changed its name to Opus Genetics, Inc. in November 2020. The company was founded in 2018 and is headquartered in Durham, North Carolina.

    Company website

    Financial statements

    Income Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Total Revenue2,157,000USD3,865,000USD3,079,000USD2,882,000USD4,370,000USD4,302,000USD3,867,000USD1,112,000USD
    Cost Of Revenue13,000USD13,000USD13,000USD6,022,000USD13,000USD7,778,000USD——
    Gross Profit2,144,000USD3,865,000USD3,079,000USD-3,140,000USD4,370,000USD-3,476,000USD3,867,000USD1,112,000USD
    Research Development10,577,000USD10,428,000USD6,409,000USD6,022,000USD7,953,000USD7,034,000USD8,982,000USD6,086,000USD
    Selling General Administrative5,944,000USD4,890,000USD4,981,000USD5,766,000USD6,346,000USD7,297,000USD2,894,000USD3,354,000USD
    Total Operating Expenses16,508,000USD15,318,000USD11,390,000USD5,766,000USD14,299,000USD34,553,000USD11,876,000USD9,440,000USD
    Operating Income-14,364,000USD-11,453,000USD-8,311,000USD-8,906,000USD-9,929,000USD-38,029,000USD-8,009,000USD-8,328,000USD
    Interest Expense651,000USD1,398,000USD68,000USD35,000USD1,372,000USD0USD0USD0USD
    Net Interest Income-651,000USD-61,000USD-68,000USD35,000USD-1,372,000USD0USD500,000USD0USD
    Income Before Tax-65,535,000USD-16,523,000USD-17,454,000USD-7,420,000USD-8,194,000USD-35,135,000USD-7,526,000USD-7,765,000USD
    Tax Provision0USD0USD0USD0USD0USD0USD0USD0USD
    Net Income-65,535,000USD-16,523,000USD-17,454,000USD-7,420,000USD-8,194,000USD-35,135,000USD-7,526,000USD-7,765,000USD
    Net Income From Continuing Ops-65,535,000USD-16,523,000USD-17,454,000USD-7,420,000USD-8,194,000USD-35,135,000USD-7,526,000USD-7,765,000USD
    Ebit-14,364,000USD-15,125,000USD-17,386,000USD-8,906,000USD-6,822,000USD-10,029,000USD——
    Ebitda-14,351,000USD-15,112,000USD-17,373,000USD-8,892,000USD-6,809,000USD-10,026,500USD-7,526,000USD-8,328,000USD
    Depreciation And Amortization13,000USD13,000USD13,000USD14,000USD13,000USD2,500USD——
    Reconciled Depreciation13,000USD13,000USD13,000USD14,000USD13,000USD10,000USD0USD0USD
    Total Other Income Expense Net-51,171,000USD-5,070,000USD-9,143,000USD1,486,000USD1,735,000USD2,894,000USD483,000USD563,000USD
    Unclassified Operating Expenses———-6,022,000USD—20,195,000USD——
    Selling And Marketing Expenses—————27,000USD——
    Interest Income——————500,000USD—
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Income Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USDFY 20212021-12-31 · USDFY 20202020-12-31 · USDFY 20192019-12-31 · USD
    Total Revenue14,196,000USD10,992,000USD19,049,000USD39,850,000USD589,000USD0USD—
    Cost Of Revenue53,000USD10,000USD6,000USD4,000USD4,000USD8,000USD—
    Gross Profit14,196,000USD10,992,000USD19,049,000USD39,850,000USD589,000USD-8,000USD—
    Research Development30,812,000USD26,851,000USD17,653,000USD14,355,000USD15,173,000USD6,648,000USD2,373,000USD
    Selling General Administrative21,983,000USD18,215,000USD11,959,000USD7,269,000USD8,121,000USD2,818,000USD1,820,000USD
    Total Operating Expenses52,795,000USD73,066,000USD29,612,000USD21,624,000USD23,294,000USD19,968,000USD4,193,000USD
    Operating Income-38,599,000USD-62,074,000USD-10,563,000USD18,226,000USD-22,705,000USD-19,968,000USD-4,193,000USD
    Interest Expense1,466,000USD0USD1,328,000USD9,000USD2,000USD6,847,000USD1,409,000USD
    Net Interest Income-1,466,000USD0USD-1,328,000USD-9,000USD-2,000USD-6,847,000USD—
    Income Before Tax-49,591,000USD-57,532,000USD-9,974,000USD18,203,000USD-56,693,000USD-24,620,000USD-6,169,000USD
    Tax Provision0USD0USD12,000USD315,000USD0USD0USD—
    Net Income-49,591,000USD-57,532,000USD-9,986,000USD17,888,000USD-56,693,000USD-24,620,000USD-6,169,000USD
    Net Income From Continuing Ops-49,591,000USD-57,532,000USD-9,986,000USD17,888,000USD-56,693,000USD-24,620,000USD—
    Ebit-48,125,000USD-57,532,000USD-9,974,000USD18,212,000USD-56,691,000USD-17,773,000USD-4,760,000USD
    Ebitda-48,072,000USD-57,522,000USD-9,968,000USD18,216,000USD-56,687,000USD-17,765,000USD-4,757,000USD
    Depreciation And Amortization53,000USD10,000USD6,000USD4,000USD4,000USD8,000USD3,000USD
    Reconciled Depreciation53,000USD10,000USD6,000USD4,000USD4,000USD8,000USD—
    Total Other Income Expense Net-10,992,000USD4,542,000USD589,000USD-23,000USD-33,988,000USD-4,652,000USD-1,976,000USD
    Unclassified Operating Expenses—28,000,000USD———10,502,000USD—
    Income Tax Expense——12,000USD315,000USD———
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Total Assets66,787,000USD50,243,000USD36,122,000USD38,665,000USD48,167,000USD36,862,000USD40,389,000USD44,834,000USD
    Other Current Assets3,927,000USD1,788,000USD815,000USD1,433,000USD1,380,000USD515,000USD429,000USD1,114,000USD
    Total Liab112,623,000USD34,895,000USD30,155,000USD21,192,000USD43,094,000USD30,138,000USD6,089,000USD4,198,000USD
    Total Stockholder Equity-45,836,000USD15,348,000USD5,967,000USD17,473,000USD5,073,000USD6,724,000USD34,300,000USD40,636,000USD
    Other Current Liab4,918,000USD4,488,000USD26,692,000USD18,727,000USD21,821,000USD8,147,000USD5,245,000USD3,564,000USD
    Common Stock7,000USD7,000USD6,000USD6,000USD5,000USD3,000USD3,000USD3,000USD
    Capital Stock7,000USD7,000USD6,000USD6,000USD5,000USD3,000USD3,000USD3,000USD
    Retained Earnings-254,124,000USD-188,589,000USD-172,066,000USD-154,612,000USD-147,192,000USD-138,998,000USD-103,863,000USD-96,337,000USD
    Cash59,959,000USD45,091,000USD30,815,000USD32,429,000USD41,792,000USD30,321,000USD36,632,000USD41,409,000USD
    Cash And Short Term Investments59,959,000USD45,091,000USD30,815,000USD32,429,000USD41,793,000USD30,323,000USD36,635,000USD41,414,000USD
    Total Current Assets66,601,000USD50,044,000USD35,910,000USD38,439,000USD47,928,000USD36,610,000USD40,389,000USD44,834,000USD
    Total Current Liabilities9,340,000USD7,781,000USD29,087,000USD20,192,000USD24,251,000USD11,295,000USD6,089,000USD4,198,000USD
    Net Debt-34,025,000USD-45,091,000USD-29,747,000USD-31,429,000USD-41,792,000USD-30,321,000USD-36,632,000USD-41,409,000USD
    Short Long Term Debt Total25,934,000USD—1,068,000USD1,000,000USD18,843,000USD18,843,000USD——
    Long Term Debt1,198,000USD1,129,000USD1,068,000USD1,000,000USD————
    Net Receivables2,715,000USD3,165,000USD4,280,000USD4,577,000USD4,755,000USD5,772,000USD3,325,000USD2,306,000USD
    Accounts Payable4,422,000USD3,293,000USD2,395,000USD1,465,000USD2,430,000USD3,148,000USD844,000USD634,000USD
    Property Plant Equipment Net186,000USD199,000USD212,000USD226,000USD239,000USD252,000USD0USD0USD
    Common Stock Shares Outstanding868,913,520shares622,219,010shares70,636,887shares63,376,392shares33,884,920shares31,574,657shares26,145,080shares25,827,265shares
    Non Current Assets Total186,000USD199,000USD212,000USD226,000USD239,000USD252,000USD0USD0USD
    Non Current Liabilities Total103,283,000USD27,114,000USD1,068,000USD1,000,000USD18,843,000USD18,843,000USD0USD0USD
    Net Working Capital57,261,000USD42,263,000USD6,823,000USD18,247,000USD23,677,000USD25,315,000USD34,300,000USD40,636,000USD
    Unclassified Non Current Liabilities102,085,000USD25,985,000USD——18,843,000USD18,843,000USD——
    Unclassified Equity208,274,000USD203,923,000USD178,021,000USD172,073,000USD152,255,000USD145,716,000USD138,157,000USD136,967,000USD
    Short Term Investments—0USD0USD0USD1,000USD2,000USD3,000USD5,000USD
    Accumulated Other Comprehensive Income———0USD————
    Property Plant Equipment Gross——————25,000USD25,000USD
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USDFY 20212021-12-31 · USDFY 20202020-12-31 · USDFY 20192019-12-31 · USD
    Total Assets50,243,000USD36,862,000USD53,948,000USD48,992,000USD26,077,000USD17,682,000USD1,784,000USD
    Other Current Assets1,788,000USD515,000USD1,099,000USD1,453,000USD1,314,000USD1,269,000USD100,000USD
    Total Liab34,895,000USD30,138,000USD4,042,000USD2,753,000USD3,855,000USD31,149,000USD9,344,000USD
    Total Stockholder Equity15,348,000USD6,724,000USD49,906,000USD46,239,000USD22,222,000USD-13,467,000USD-7,560,000USD
    Other Current Liab4,488,000USD8,147,000USD1,889,000USD1,369,000USD1,733,000USD1,971,000USD3,335,000USD
    Common Stock7,000USD3,000USD2,000USD2,000USD2,000USD1,000USD—
    Capital Stock7,000USD3,000USD2,000USD2,000USD2,000USD1,000USD—
    Retained Earnings-188,589,000USD-138,998,000USD-81,466,000USD-71,480,000USD-89,368,000USD-32,675,000USD-8,055,000USD
    Cash45,091,000USD30,321,000USD50,501,000USD42,634,000USD24,534,000USD16,399,000USD1,537,000USD
    Cash And Short Term Investments45,091,000USD30,323,000USD50,516,000USD42,683,000USD24,753,000USD16,399,000USD1,537,000USD
    Total Current Assets50,044,000USD36,610,000USD53,948,000USD48,986,000USD26,067,000USD17,668,000USD1,762,000USD
    Total Current Liabilities7,781,000USD11,295,000USD4,042,000USD2,753,000USD3,855,000USD3,185,000USD9,344,000USD
    Net Debt-45,091,000USD-30,321,000USD-50,501,000USD-42,634,000USD-23,996,000USD-16,399,000USD4,130,000USD
    Long Term Debt1,129,000USD——————
    Short Term Investments0USD2,000USD15,000USD49,000USD219,000USD0USD—
    Net Receivables3,165,000USD5,772,000USD2,333,000USD4,850,000USD0USD—125,000USD
    Accounts Payable3,293,000USD3,148,000USD2,153,000USD1,069,000USD1,584,000USD1,214,000USD342,000USD
    Property Plant Equipment Net199,000USD252,000USD0USD6,000USD10,000USD14,000USD22,000USD
    Common Stock Shares Outstanding622,219,010shares26,715,526shares21,589,821shares20,597,212shares14,852,745shares4,661,110shares7,091,878shares
    Non Current Assets Total199,000USD252,000USD0USD6,000USD10,000USD14,000USD22,000USD
    Non Current Liabilities Total27,114,000USD18,843,000USD0USD635,999USD0USD27,964,000USD—
    Net Working Capital42,263,000USD25,315,000USD49,906,000USD46,233,000USD22,212,000USD14,483,000USD—
    Unclassified Non Current Liabilities25,985,000USD18,843,000USD———27,964,000USD—
    Unclassified Equity203,923,000USD145,716,000USD131,368,000USD117,715,000USD111,586,000USD19,206,000USD—
    Short Long Term Debt Total—18,843,000USD——538,000USD—5,667,000USD
    Property Plant Equipment Gross——25,000USD25,000USD25,000USD25,000USD—
    Short Term Debt————538,000USD—5,667,000USD
    Short Long Term Debt————538,000USD——
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Net Income-65,535,000USD-16,523,000USD-17,454,000USD-7,420,000USD-8,194,000USD-35,135,000USD-7,526,000USD-7,765,000USD
    Depreciation13,000USD13,000USD13,000USD14,000USD13,000USD10,000USD0USD0USD
    Stock Based Compensation1,464,000USD774,000USD816,000USD896,000USD913,000USD795,000USD776,000USD806,000USD
    Other Non Cash Items52,897,000USD6,604,000USD9,593,000USD-951,000USD-1,432,000USD25,482,000USD2,000USD—
    Change To Account Receivables450,000USD1,115,000USD297,000USD178,000USD1,017,000USD-2,447,000USD-1,019,000USD812,000USD
    Change In Working Capital-102,000USD73,000USD875,000USD-2,808,000USD-294,000USD1,410,000USD1,618,000USD-333,000USD
    Total Cash From Operating Activities-12,727,000USD-9,833,000USD-6,157,000USD-10,269,000USD-8,994,000USD-7,438,000USD-5,130,000USD-7,292,000USD
    Capital Expenditures0USD0USD0USD0USD0USD0USD0USD0USD
    Free Cash Flow-12,727,000USD-9,833,000USD-6,157,000USD-10,269,000USD-8,994,000USD-7,438,000USD-5,130,000USD-7,292,000USD
    Total Cash From Financing Activities27,595,000USD24,109,000USD4,543,000USD906,000USD20,465,000USD-83,000USD353,000USD1,540,000USD
    Sale Purchase Of Stock-393,000USD-116,000USD5,217,000USD445,000USD-36,000USD-37,000USD0USD0USD
    Issuance Of Capital Stock27,250,000USD23,178,000USD5,217,000USD0USD6,389,000USD0USD456,000USD1,562,000USD
    Change In Cash14,868,000USD14,276,000USD-1,614,000USD-9,363,000USD11,471,000USD-6,311,000USD-4,777,000USD-5,752,000USD
    Begin Period Cash Flow45,091,000USD30,815,000USD32,429,000USD41,792,000USD30,321,000USD36,632,000USD41,409,000USD47,161,000USD
    End Period Cash Flow59,959,000USD45,091,000USD30,815,000USD32,429,000USD41,792,000USD30,321,000USD36,632,000USD41,409,000USD
    Other Cashflows From Financing Activities27,595,000USD—4,543,000USD906,000USD14,112,000USD-46,000USD-103,000USD-22,000USD
    Unclassified Operating Cash Flow-1,464,000USD———————
    Unclassified Financing Cash Flow—24,225,000USD-5,217,000USD—6,389,000USD——1,562,000USD
    Investments——0USD0USD0USD1,210,000USD0USD0USD
    Total Cashflows From Investing Activities—————1,210,000USD——
    Other Cashflows From Investing Activities—————1,210,000USD——
    Unclassified Investing Cash Flow—————-1,210,000USD——
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USDFY 20212021-12-31 · USDFY 20202020-12-31 · USDFY 20192019-12-31 · USD
    Net Income-49,591,000USD-57,532,000USD-9,986,000USD17,888,000USD-56,693,000USD-24,620,000USD-6,169,000USD
    Depreciation53,000USD10,000USD6,000USD4,000USD4,000USD8,000USD3,000USD
    Stock Based Compensation3,399,000USD3,362,000USD3,510,000USD1,807,000USD1,914,000USD1,506,000USD308,000USD
    Other Non Cash Items13,040,000USD25,494,000USD1,282,000USD170,000USD35,224,000USD15,163,000USD1,908,000USD
    Change To Account Receivables2,607,000USD-3,439,000USD2,517,000USD-4,850,000USD0USD——
    Change In Working Capital-2,154,000USD3,090,000USD4,076,000USD-5,555,000USD181,000USD1,146,000USD357,000USD
    Total Cash From Operating Activities-35,253,000USD-25,576,000USD-1,112,000USD14,314,000USD-19,370,000USD-6,797,000USD-3,593,000USD
    Capital Expenditures0USD0USD0USD0USD0USD0USD-25,000USD
    Free Cash Flow-35,253,000USD-25,576,000USD-1,112,000USD14,314,000USD-19,370,000USD-6,797,000USD-3,618,000USD
    Total Cash From Financing Activities50,023,000USD4,186,000USD8,979,000USD3,786,000USD27,605,000USD21,120,000USD4,704,000USD
    Sale Purchase Of Stock-152,000USD-79,000USD0USD————
    Issuance Of Capital Stock34,784,000USD4,497,000USD9,227,000USD4,428,000USD28,491,000USD21,150,000USD—
    Change In Cash14,770,000USD-20,180,000USD7,867,000USD18,100,000USD8,135,000USD14,862,000USD1,086,000USD
    Begin Period Cash Flow30,321,000USD50,501,000USD42,634,000USD24,534,000USD16,399,000USD1,537,000USD451,000USD
    End Period Cash Flow45,091,000USD30,321,000USD50,501,000USD42,634,000USD24,534,000USD16,399,000USD1,537,000USD
    Other Cashflows From Financing Activities50,023,000USD-232,000USD-248,000USD-104,000USD-1,424,000USD-2,227,000USD-2,000USD
    Investments—1,210,000USD0USD0USD-100,000USD539,000USD—
    Total Cashflows From Investing Activities—1,210,000USD——-100,000USD539,000USD-25,000USD
    Other Cashflows From Investing Activities—1,210,000USD——-100,000USD539,000USD—
    Unclassified Investing Cash Flow—-1,210,000USD—————
    Unclassified Financing Cash Flow—4,497,000USD9,227,000USD——2,197,000USD4,706,000USD
    Net Borrowings——0USD-538,000USD538,000USD——
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Operating metrics

    No operating metrics are currently published for this company.

    Revenue breakdown

    PeriodDimensionBusiness / regionRevenueCurrencySource
    FY 2022Yearly · 2022-12-31ProductLicense Transfer Fee39,519,000USD0001140361-23-014868
    FY 2022Yearly · 2022-12-31ProductResearch Development Services331,000USD0001140361-23-014868

    Periods follow company fiscal calendars. Quarterly, annual and year-to-date amounts are shown separately. Missing values are not zero. Data may be delayed, incomplete or corrected; follow the disclosure links to verify figures.