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    GPCR

    Structure Therapeutics Inc.

    Company overview

    Market capitalization
    $7.50B
    Employees
    233
    Latest publication
    2026-09-29
    About Structure Therapeutics Inc.

    Structure Therapeutics Inc., a clinical stage global biopharmaceutical company, develops and delivers novel oral small molecule therapeutics to treat various chronic diseases with unmet medical needs in the United States. Its lead product candidate is GSBR-1290, an oral and biased small molecule agonist of glucagon-like-peptide-1 receptor, which is in two phase 2 clinical trials for the treatment of obesity, overweight, and related conditions. The company also develops ACCG-2671 and ACCG-3535, an oral small molecule amylin receptor agonist that is in phase1 clinical trial for the treatment of obesity; ANPA-0073, an oral small molecule APJ receptor agonist; and LTSE-2578, an antagonist that targets lysophosphatidic acid 1 receptor, a G-protein coupled receptors implicated in responses to tissue injury and pro-fibrotic processes, for the treatment of idiopathic pulmonary fibrosis. In addition, it develops programs, including glucose-dependent insulinotropic polypeptide receptor (GIPR) program, which identified multiple GIPR agonist, dual GLP-1R/GIPR agonist, and GIPR antagonist hits for small molecule GIPR modulation that has the potential to provide a treatment in obesity; and GCG program, which identified multiple GCG receptor (GCGR) agonist and dual GLP-1R/GCGR agonist hits for small molecule GCGR modulation. The company was formerly known as ShouTi Inc. Structure Therapeutics Inc. was incorporated in 2016 and is headquartered in South San Francisco, California.

    Company website

    Financial statements

    Income Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ2 20262026-06-30 · USDQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USD
    Operating Income-118,630,000USD-89,645,505USD23,989,000USD-73,787,000USD-70,451,000USD-56,311,000USD-47,061,000USD-45,836,000USD
    Net Income-106,159,000USD-76,194,517USD33,004,000USD-65,712,000USD-61,661,000USD-46,833,000USD-36,479,000USD-33,977,000USD
    Total Revenue—0USD0USD0USD0USD0USD1,781,326USD0USD
    Cost Of Revenue—1,218,622USD——853,991USD686,976USD—267,175USD
    Gross Profit—-1,218,622USD——-853,991USD-686,976USD890,663USD-267,175USD
    Research Development—66,705,307USD68,689,000USD58,989,000USD54,710,000USD42,867,000USD33,487,000USD32,598,000USD
    Selling General Administrative—22,872,000USD17,571,000USD14,798,000USD15,741,000USD13,444,000USD13,574,000USD13,238,000USD
    Unclassified Operating Expenses—-1,150,424USD-110,249,000USD—————
    Total Operating Expenses—88,426,883USD-23,989,000USD73,787,000USD70,451,000USD56,311,000USD47,061,000USD45,836,000USD
    Net Interest Income—13,601,000USD9,185,000USD8,183,000USD8,929,000USD9,576,000USD10,718,000USD11,951,000USD
    Income Before Tax—-76,003,951USD33,174,000USD-65,604,000USD-61,522,000USD-46,735,000USD-36,343,000USD-33,885,000USD
    Income Tax Expense—190,566USD170,000USD108,000USD139,000USD98,000USD136,000USD92,000USD
    Tax Provision—190,000USD170,000USD108,000USD139,000USD98,000USD136,000USD92,000USD
    Net Income From Continuing Ops—-75,968,000USD33,004,000USD-65,712,000USD-61,661,000USD-46,833,000USD-36,479,000USD-33,977,000USD
    Ebit—-76,003,951USD33,174,000USD-65,604,000USD-61,522,000USD-46,735,000USD-36,343,000USD-33,885,000USD
    Ebitda—-74,785,329USD33,586,000USD-65,313,000USD-61,231,000USD-46,461,000USD-36,070,000USD-33,620,000USD
    Depreciation And Amortization—1,218,622USD412,000USD291,000USD291,000USD274,000USD273,000USD265,000USD
    Reconciled Depreciation—576,000USD412,000USD356,000USD291,000USD274,000USD273,000USD265,000USD
    Total Other Income Expense Net—13,641,554USD9,185,000USD8,183,000USD8,929,000USD9,576,000USD10,718,000USD11,951,000USD
    SourceDisclosureVerifiedLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Income Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USDFY 20202020-12-31 · USD
    Total Revenue0USD0USD0USD0USD0USD
    Cost Of Revenue3,899,285USD2,598,302USD949,174USD623,258USD20,034USD
    Gross Profit-3,899,285USD-2,598,302USD-949,174USD-623,258USD-20,034USD
    Research Development225,255,000USD108,814,000USD70,103,000USD36,193,000USD12,364USD
    Selling General Administrative61,554,000USD49,414,000USD32,672,000USD16,368,000USD3,542USD
    Unclassified Operating Expenses-3,140,752USD————
    Total Operating Expenses283,668,248USD158,228,000USD102,775,000USD52,561,000USD15,906USD
    Operating Income-287,567,533USD-158,228,000USD-102,775,000USD-52,561,000USD-15,906USD
    Net Interest Income35,873,000USD36,012,000USD13,391,000USD1,257,000USD168USD
    Income Before Tax-140,687,000USD-122,216,000USD-89,384,000USD-51,304,000USD-15,738USD
    Income Tax Expense515,000USD310,000USD236,000USD17,000USD138USD
    Tax Provision515,000USD310,000USD236,000USD17,000USD138USD
    Net Income-141,202,000USD-122,526,000USD-89,620,000USD-51,321,000USD-15,876USD
    Net Income From Continuing Ops-141,202,000USD-122,526,000USD-89,620,000USD-51,321,000USD-15,876USD
    Ebit-140,687,000USD-122,216,000USD-75,993,000USD-52,561,000USD-15,906USD
    Ebitda-136,787,715USD-121,224,000USD-75,698,000USD-52,284,000USD-15,906USD
    Depreciation And Amortization3,899,285USD992,000USD295,000USD277,000USD20,034USD
    Reconciled Depreciation1,333,000USD992,000USD295,000USD277,000USD0USD
    Total Other Income Expense Net146,508,454USD36,012,000USD13,391,000USD1,257,000USD168USD
    Selling And Marketing Expenses——1USD——
    Interest Expense——13,391,000USD1,534,000USD5USD
    Minority Interest———0USD—
    Other Operating Expenses————15,906USD
    Net Income Applicable To Common Shares————-16,039,000USD
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ2 20262026-06-30 · USDQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USD
    Total Assets1,425,415,000USD1,508,124,000USD1,583,918,000USD832,159,000USD816,443,000USD866,549,000USD903,330,000USD933,217,000USD
    Cash And Equivalents272,638,000USD———————
    Cash And Short Term Investments1,342,700,000USD1,458,504,000USD1,446,197,000USD799,043,000USD786,496,000USD836,882,000USD883,518,000USD915,286,000USD
    Short Term Investments1,070,020,000USD1,142,336,000USD646,574,000USD696,131,000USD639,472,000USD684,759,000USD714,008,000USD743,156,000USD
    Total Current Assets1,372,028,000USD1,490,598,000USD1,570,303,000USD814,022,000USD799,298,000USD849,622,000USD891,211,000USD923,651,000USD
    Other Current Assets29,370,000USD32,094,000USD124,106,000USD14,979,000USD12,802,000USD12,740,000USD7,693,000USD8,365,000USD
    Other Non Current Assets40,995,000USD———————
    Total Liabilities71,011,000USD———————
    Total Current Liabilities66,113,000USD56,984,000USD63,285,000USD57,527,000USD39,033,000USD36,487,000USD36,021,000USD33,434,000USD
    Other Non Current Liabilities1,265,000USD———————
    Total Stockholder Equity1,354,404,000USD1,447,094,000USD1,516,377,000USD770,019,000USD772,081,000USD824,638,000USD864,843,000USD896,801,000USD
    Total Equity Including Noncontrolling Interest1,354,404,000USD———————
    Property Plant Equipment Net12,392,000USD11,971,000USD12,898,000USD11,538,000USD10,943,000USD10,831,000USD7,013,000USD7,744,000USD
    Accounts Payable11,131,000USD7,822,000USD13,864,000USD17,796,000USD8,990,000USD8,710,000USD8,024,000USD8,447,000USD
    Short Term Debt2,595,000USD2,609,000USD2,878,000USD2,802,000USD2,664,000USD2,471,000USD1,698,000USD1,712,000USD
    Common Stock21,000USD21,000USD21,000USD18,000USD17,000USD17,000USD17,000USD17,000USD
    Retained Earnings-652,427,000USD-546,268,000USD-470,300,000USD-503,304,000USD-437,592,000USD-375,931,000USD-329,098,000USD-292,619,000USD
    Accumulated Other Comprehensive Income-3,445,000USD-2,195,000USD1,054,000USD825,000USD362,000USD815,000USD914,000USD2,839,000USD
    Total Liab—61,030,000USD67,541,000USD62,140,000USD44,362,000USD41,911,000USD38,487,000USD36,416,000USD
    Other Current Liab—46,553,000USD46,543,000USD36,929,000USD27,379,000USD25,306,000USD26,299,000USD23,136,000USD
    Capital Stock—21,000USD21,000USD18,000USD17,000USD17,000USD17,000USD17,000USD
    Cash—316,168,000USD799,623,000USD102,912,000USD147,024,000USD152,123,000USD169,510,000USD172,130,000USD
    Net Debt—-310,376,000USD-793,136,000USD-95,822,000USD-139,348,000USD-144,536,000USD-165,648,000USD-167,745,000USD
    Short Long Term Debt Total—5,792,000USD6,487,000USD7,090,000USD7,676,000USD7,587,000USD3,862,000USD4,385,000USD
    Property Plant Equipment Gross—11,971,000USD15,867,000USD11,538,000USD10,943,000USD10,831,000USD8,649,000USD9,107,000USD
    Common Stock Shares Outstanding—72,442,000shares59,198,666shares58,489,666shares57,919,833shares57,350,000shares57,287,000shares57,210,000shares
    Non Current Assets Total—17,526,000USD13,615,000USD18,137,000USD17,145,000USD16,927,000USD12,119,000USD9,566,000USD
    Non Current Liabilities Total—4,046,000USD4,256,000USD4,613,000USD5,329,000USD5,424,000USD2,466,000USD2,982,000USD
    Non Current Liabilities Other—863,000USD647,000USD325,000USD317,000USD308,000USD302,000USD309,000USD
    Non Currrent Assets Other—5,555,000USD717,000USD6,599,000USD6,202,000USD6,096,000USD5,106,000USD1,822,000USD
    Net Working Capital—1,433,614,000USD1,507,018,000USD756,495,000USD760,265,000USD813,135,000USD855,190,000USD890,217,000USD
    Unclassified Non Current Liabilities—3,183,000USD3,609,000USD4,288,000USD5,012,000USD5,116,000USD2,164,000USD2,673,000USD
    Unclassified Equity—1,995,515,000USD1,985,581,000USD1,272,462,000USD1,209,277,000USD1,199,720,000USD1,192,993,000USD1,186,547,000USD
    SourceDisclosureDeterministicFinalLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Balance sheet Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USDFY 20212021-12-31 · USDFY 20202020-12-31 · USD
    Total Assets1,583,918,000USD903,330,000USD482,017,000USD97,845,000USD111,155,000USD38,704,000USD
    Other Current Assets124,106,000USD7,693,000USD6,285,000USD2,248,000USD1,943,000USD974,000USD
    Total Liab67,541,000USD38,487,000USD29,051,000USD212,985,000USD175,890,000USD61,173,000USD
    Total Stockholder Equity1,516,377,000USD864,843,000USD452,966,000USD-115,140,000USD-64,735,000USD-22,469,000USD
    Other Current Liab46,543,000USD26,299,000USD18,202,000USD6,567,000USD4,594,000USD1,227,000USD
    Common Stock21,000USD17,000USD14,000USD1,000USD1,000USD1,000USD
    Capital Stock21,000USD17,000USD14,000USD1,000USD1USD1USD
    Retained Earnings-470,300,000USD-329,098,000USD-206,572,000USD-116,952,000USD-64,736,000USD-22,946,000USD
    Cash799,623,000USD169,510,000USD129,792,000USD26,091,000USD105,305,000USD16,352,000USD
    Cash And Short Term Investments1,446,197,000USD883,518,000USD467,323,000USD90,841,000USD107,307,000USD37,445,000USD
    Total Current Assets1,570,303,000USD891,211,000USD473,608,000USD93,089,000USD109,250,000USD38,419,000USD
    Total Current Liabilities63,285,000USD36,021,000USD24,740,000USD13,010,000USD8,658,000USD3,039,000USD
    Net Debt-793,136,000USD-165,648,000USD-124,339,000USD-25,831,000USD-104,684,000USD-16,072,000USD
    Short Term Debt2,878,000USD1,698,000USD1,440,000USD260,000USD349,000USD147,000USD
    Short Long Term Debt Total6,487,000USD3,862,000USD5,453,000USD260,000USD621,000USD280,000USD
    Short Term Investments646,574,000USD714,008,000USD337,531,000USD64,750,000USD2,002,000USD21,093,000USD
    Accounts Payable13,864,000USD8,024,000USD4,742,000USD6,009,000USD3,484,000USD1,527,000USD
    Property Plant Equipment Net12,898,000USD7,013,000USD8,364,000USD1,293,000USD1,794,000USD277,000USD
    Property Plant Equipment Gross15,867,000USD8,649,000USD9,008,000USD1,293,000USD1,866USD277USD
    Accumulated Other Comprehensive Income1,054,000USD914,000USD521,000USD-110,000USD-166,957,428USD-1,000USD
    Common Stock Shares Outstanding59,198,666shares52,641,000shares36,733,000shares36,588,000shares36,588,000shares36,588,000shares
    Non Current Assets Total13,615,000USD12,119,000USD8,409,000USD4,756,000USD1,905,000USD285,000USD
    Non Current Liabilities Total4,256,000USD2,466,000USD4,311,000USD199,975,000USD167,232,000USD58,134,000USD
    Non Current Liabilities Other647,000USD302,000USD298,000USD———
    Non Currrent Assets Other717,000USD5,106,000USD45,000USD3,463,000USD111,000USD8,000USD
    Net Working Capital1,507,018,000USD855,190,000USD448,868,000USD80,079,000USD100,592USD35,380USD
    Unclassified Non Current Liabilities3,609,000USD2,164,000USD4,013,000USD196,575,000USD167,132,000USD58,134,000USD
    Unclassified Equity1,985,581,000USD1,192,993,000USD658,989,000USD1,920,000USD166,957,427USD—
    Other Assets——1USD3,463,000USD111,000USD8,000USD
    Current Deferred Revenue——356,001USD———
    Deferred Long Term Liab———3,400,000USD100,000USD—
    Net Tangible Assets———-115,140,000USD-64,735,000USD-22,469,000USD
    Unclassified Non Current Assets———-3,463,000USD——
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow YTD

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ2 20262026-06-30 · USD
    Depreciation1,127,000USD
    Stock Based Compensation24,273,000USD
    Change To Liabilities-1,308,000USD
    Change In Working Capital-47,200,000USD
    Operating Cash Flow-104,881,000USD
    Capital Expenditures-1,140,000USD
    Unclassified Investing Cash Flow-421,307,000USD
    Investing Cash Flow-422,447,000USD
    Net Common Stock Issuance-2,574,000USD
    Unclassified Financing Cash Flow2,917,000USD
    Financing Cash Flow343,000USD
    Change In Cash-526,985,000USD
    End Cash Flow272,638,000USD
    SourceDisclosureDeterministicFinal

    Cash flow Quarterly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricQ1 20262026-03-31 · USDQ4 20252025-12-31 · USDQ3 20252025-09-30 · USDQ2 20252025-06-30 · USDQ1 20252025-03-31 · USDQ4 20242024-12-31 · USDQ3 20242024-09-30 · USDQ2 20242024-06-30 · USD
    Net Income-76,194,517USD33,004,000USD-65,712,000USD-61,661,000USD-46,833,000USD-36,479,000USD-33,977,000USD-26,034,000USD
    Depreciation576,000USD412,000USD356,000USD291,000USD274,000USD273,000USD265,000USD232,000USD
    Stock Based Compensation11,639,000USD8,069,000USD7,495,000USD7,509,000USD5,918,000USD5,831,000USD6,023,000USD4,196,000USD
    Other Non Cash Items-2,568,323USD-11,823,711USD-2,647,000USD-3,780,000USD-4,785,000USD-5,558,000USD-5,710,000USD-2,753,000USD
    Change To Account Receivables100,298,175USD———————
    Change In Working Capital81,827,263USD-94,077,289USD9,512,000USD3,083,000USD-6,803,000USD-534,000USD13,703,000USD-2,034,000USD
    Total Cash From Operating Activities15,279,423USD-64,416,000USD-50,996,000USD-54,558,000USD-52,229,000USD-36,467,000USD-19,696,000USD-26,393,000USD
    Capital Expenditures-1,185,523USD-1,496,000USD-1,572,000USD-232,000USD-314,000USD-16,000USD-685,000USD-427,000USD
    Free Cash Flow14,093,900USD-65,912,000USD-52,568,000USD-54,790,000USD-52,543,000USD-36,483,000USD-20,381,000USD-26,820,000USD
    Investments-495,765,000USD62,794,000USD-49,319,000USD48,942,000USD34,033,000USD33,232,000USD-189,044,000USD-204,515,000USD
    Total Cashflows From Investing Activities-498,428,772USD56,140,000USD-49,319,000USD48,942,000USD34,033,000USD33,232,000USD-189,044,000USD-204,515,000USD
    Total Cash From Financing Activities-1,747,194USD704,987,000USD56,203,000USD517,000USD809,000USD615,000USD-757,000USD514,703,000USD
    Change In Cash-483,448,599USD696,714,425USD-44,112,000USD-5,099,000USD-17,387,000USD-2,620,000USD-209,497,000USD283,795,000USD
    Begin Period Cash Flow799,626,410USD102,911,985USD147,024,000USD152,123,000USD169,510,000USD172,130,000USD381,627,000USD97,832,000USD
    End Period Cash Flow316,177,811USD799,626,410USD102,912,000USD147,024,000USD152,123,000USD169,510,000USD172,130,000USD381,627,000USD
    Other Cashflows From Financing Activities-2,581,674USD-3,928,735USD-855,000USD-2,268USD-157,373USD615,000USD-757,000USD130,000USD
    Issuance Of Capital Stock—608,650,000USD57,058,000USD——0USD0USD514,573,000USD
    Other Cashflows From Investing Activities—5,091,000USD5,158,000USD—34,347,000USD33,248,000USD273,000USD-275,000USD
    Unclassified Investing Cash Flow—-10,249,000USD-3,586,000USD—-34,033,000USD-33,232,000USD——
    Unclassified Financing Cash Flow—100,265,735USD——————
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Cash flow Yearly

    Exact reported values; units shown beside each amount. Missing values are —.
    MetricFY 20252025-12-31 · USDFY 20242024-12-31 · USDFY 20232023-12-31 · USDFY 20222022-12-31 · USDFY 20212021-12-31 · USD
    Net Income-141,202,000USD-122,526,000USD-89,620,000USD-51,321,000USD-38,049,000USD
    Depreciation1,333,000USD992,000USD295,000USD277,000USD72,000USD
    Stock Based Compensation28,991,000USD18,794,000USD8,191,000USD2,514,000USD1,487,000USD
    Other Non Cash Items-23,047,155USD-16,860,000USD-5,320,000USD-558,000USD268,000USD
    Change In Working Capital-88,273,845USD2,964,000USD6,966,000USD2,968,000USD4,062,000USD
    Total Cash From Operating Activities-222,199,000USD-116,636,000USD-79,488,000USD-46,120,000USD-32,160,000USD
    Capital Expenditures-3,614,000USD-1,290,000USD-2,167,000USD-155,000USD-1,206,000USD
    Free Cash Flow-225,813,000USD-117,926,000USD-81,655,000USD-46,275,000USD-33,366,000USD
    Investments93,410,000USD-358,909,000USD-268,342,000USD-62,108,000USD17,859USD
    Total Cashflows From Investing Activities89,796,000USD-358,909,000USD-268,342,000USD-62,108,000USD17,859,000USD
    Total Cash From Financing Activities762,516,000USD515,263,000USD451,531,000USD29,014,000USD103,254,000USD
    Issuance Of Capital Stock665,708,000USD514,573,000USD472,296,000USD31,500,000USD103,358USD
    Change In Cash630,116,877USD39,718,000USD103,701,000USD-79,214,000USD88,953,000USD
    Begin Period Cash Flow169,510,000USD129,792,000USD26,091,000USD105,305,000USD16,352,000USD
    End Period Cash Flow799,626,410USD169,510,000USD129,792,000USD26,091,000USD105,305,000USD
    Other Cashflows From Investing Activities10,249,000USD-357,619,000USD-231,377USD-61,953USD19,065USD
    Other Cashflows From Financing Activities-4,661,630USD690,000USD-20,765,000USD29,014,000USD103,254,000USD
    Unclassified Investing Cash Flow-10,249,000USD358,909,000USD——19,028,076USD
    Unclassified Financing Cash Flow101,469,630USD————
    Change To Liabilities———2,153,000USD1,897,000USD
    Sale Purchase Of Stock———-6,000USD—
    SourceLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacyLegacy providerLegacy

    Operating metrics

    No operating metrics are currently published for this company.

    Revenue breakdown

    No revenue breakdown is currently published for this company.

    Periods follow company fiscal calendars. Quarterly, annual and year-to-date amounts are shown separately. Missing values are not zero. Data may be delayed, incomplete or corrected; follow the disclosure links to verify figures.