| Rank | Company | Operating income | Sector | Industry | Country | Exchange |
|---|---|---|---|---|---|---|
| 1 | $11.4B | Healthcare | Biotechnology | United States | Nasdaq | |
| 2 | $972M | Healthcare | Biotechnology | United States | Nasdaq | |
| 3 | $795M | Healthcare | Biotechnology | United States | Nasdaq | |
| 4 | $597M | Healthcare | Biotechnology | United States | Nasdaq | |
| 5 | $252M | Healthcare | Biotechnology | United States | Nasdaq | |
| 6 | $224M | Healthcare | Biotechnology | United States | Nasdaq | |
| 7 | $198M | Healthcare | Biotechnology | United States | Nasdaq | |
| 8 | $184M | Healthcare | Biotechnology | United States | Nasdaq | |
| 9 | $64.6M | Healthcare | Biotechnology | United States | Nasdaq | |
| 10 | $36.2M | Healthcare | Biotechnology | United States | Nasdaq | |
| 11 | $23.3M | Healthcare | Biotechnology | United States | NYSE | |
| 12 | $18.2M | Healthcare | Biotechnology | United States | Nasdaq |